Can you take Freeze It with Rilpivirine?
1 drug interaction and 5 additional warnings found for the following 2 drugs:
- Freeze It (camphor/menthol topical)
- rilpivirine
Drug interactions
Minor drug interactions
Minor:
menthol topical rilpivirine
Applies to: Freeze It (camphor / menthol topical) and rilpivirine
Information for this minor interaction is available on the professional version.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
rilpivirine Food/Lifestyle
Applies to: rilpivirine
Food significantly increases the absorption of rilpivirine. You should take each dose of rilpivirine with a meal. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication. Grapefruit juice can also increase the absorption of rilpivirine and should preferably be avoided.
Disease interactions
4 potential interactions Applies to: 4 conditions, including Depression, Psychosis, Liver Disease, and Renal Dysfunction.
Depression
Moderate:
rilpivirine
Rilpivirine has a moderate potential interaction with Depression.
Depressive symptoms including suicide ideation and suicide attempts have been reported with the use of rilpivirine. Patients should be monitored for the appearance of these symptoms and should seek medical evaluation immediately if severe depressive symptoms occur. Caution should be used in patients with a history of depression or other psychiatric conditions.
Liver Disease
Moderate:
rilpivirine
Rilpivirine has a moderate potential interaction with Liver Disease.
Hepatic adverse events have been reported in patients taking rilpivirine. Patients with underlying hepatitis B or C virus infection or marked transaminase elevations prior to therapy may be at increased risk for worsening or development of transaminase elevations; a few cases of hepatic toxicity have been reported in patients without preexisting hepatic disease or other known risk factors. Appropriate laboratory testing before starting therapy and monitoring for hepatotoxicity during therapy are recommended in patients with underlying hepatic disease (e.g., hepatitis B or C virus infection) or in patients with marked baseline transaminase elevations. Rilpivirine has not been studied in patients with severe liver dysfunction (Child-Pugh C); caution is recommended.
Psychosis
Moderate:
rilpivirine
Rilpivirine has a moderate potential interaction with Psychosis.
Depressive symptoms including suicide ideation and suicide attempts have been reported with the use of rilpivirine. Patients should be monitored for the appearance of these symptoms and should seek medical evaluation immediately if severe depressive symptoms occur. Caution should be used in patients with a history of depression or other psychiatric conditions.
Renal Dysfunction
Moderate:
rilpivirine
Rilpivirine has a moderate potential interaction with Renal Dysfunction.
Rilpivirine should be used with caution and with increased monitoring for side effects in patients with severe renal dysfunction or end-stage renal disease, as drug concentrations can be increased due to alteration of drug absorption, distribution, and metabolism secondary to renal dysfunction. No dose adjustment is required in patients with mild or moderate renal dysfunction.
More resources
Freeze It
A total of 364 drugs are known to interact with Freeze It.
- Freeze it is in the drug class topical rubefacient.
- Freeze it is used to treat the following conditions:
rilpivirine
A total of 440 drugs are known to interact with rilpivirine.
- Rilpivirine is in the drug class NNRTIs.
- Rilpivirine is used to treat HIV-1 Infection.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.