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Drug Interactions between fostamatinib and Viagra

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

sildenafil fostamatinib

Applies to: Viagra (sildenafil) and fostamatinib

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with weak inhibitors of CYP450 3A4 may increase the plasma concentrations of sildenafil, which is primarily metabolized by the isoenzyme. Pharmacokinetic models predict that this interaction may be more significant for oral rather than intravenous formulations of sildenafil, due at least partly to effects from first pass metabolism. An analysis of population pharmacokinetic data from clinical trials in adult pulmonary hypertension patients indicated a reduction in sildenafil clearance of approximately 30% when coadministered with mild CYP450 3A4 inhibitors. Sildenafil labeling does not currently report study data involving concurrent use with weak CYP450 3A4 inhibitors in pediatric pulmonary hypertension patients. Likewise, sildenafil products indicated for erectile dysfunction also focus on study data with more potent CYP450 3A4 inhibitors.

MANAGEMENT: Caution is advised if sildenafil is coadministered with weak CYP450 3A4 inhibitors. The significance of this interaction may be less for intravenous formulations of sildenafil and greater in patients with risk factors for adverse effects, such as those with renal impairment, hepatic impairment, and/or elderly patients. The presence of renal and/or hepatic dysfunction may necessitate adjustments of sildenafil's dose. If concurrent administration is necessary, patients should be monitored closely for adverse reactions and may benefit from initiating sildenafil at the lowest recommended dosage with slow, careful titration. Dosage adjustments may be necessary for sildenafil whenever a CYP450 3A4 inhibitor is added to or withdrawn from therapy based on efficacy and side effects. Patients should be advised to promptly notify their physician if they experience pain or tightness in the chest or jaw, irregular heartbeat, nausea, shortness of breath, visual disturbances, syncope, or prolonged erection (greater than 4 hours).

Drug and food interactions

Moderate

sildenafil food

Applies to: Viagra (sildenafil)

If you are receiving therapy with sildenafil you should avoid the regular consumption of large amounts of grapefruits and grapefruit juice. Grapefruit can raise the levels of sildenafil in your body and delay the time it takes for the medication to work. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.