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Drug Interactions between fospropofol and nitrous oxide

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

nitrous oxide fospropofol

Applies to: nitrous oxide and fospropofol

ADJUST DOSE: Premedication with morphine (0.15 mg/kg) and nitrous oxide (67% in oxygen) has been shown to decrease maintenance infusion rates of propofol relative to infusion rates required with nonnarcotic premedication (e.g., lorazepam).

MANAGEMENT: If morphine and nitrous oxide are used as premedications, the rate of propofol infusion should be adjusted according to the patient's clinical response.

References (3)
  1. (2001) "Product Information. Diprivan (propofol)." Astra-Zeneca Pharmaceuticals
  2. Pavlin DJ, Coda B, Shen DD, et al. (1996) "Effects of combining propofol and alfentanil on ventilation, analgesia, sedation, and emesis in human volunteers." Anesthesiology, 84, p. 23-37
  3. (2024) "Product Information. propOFol Lipuro (B Braun) (propOFol)." B Braun Australia Pty Ltd, 3

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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