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Drug Interactions between fosphenytoin and Zovirax

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

acyclovir fosphenytoin

Applies to: Zovirax (acyclovir) and fosphenytoin

MONITOR: A case report suggests that plasma phenytoin concentrations may be decreased in the presence of acyclovir. Seizure activity may increase. The mechanism is unknown. A similar interaction may theoretically occur with other hydantoins.

MANAGEMENT: The clinician should consider closer clinical and laboratory monitoring if acyclovir therapy is started or stopped in the presence of phenytoin. The dose of phenytoin should be adjusted as clinically indicated. Patients should be advised to report loss of seizure control.

References (1)
  1. Parmeggiani A, Riva R, Posar A, Rossi PG (1995) "Possible interaction between acyclovir and antiepileptic treatment." Ther Drug Monit, 17, p. 312-5

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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