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Drug Interactions between fosphenytoin and rifabutin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

rifabutin fosphenytoin

Applies to: rifabutin and fosphenytoin

MONITOR: Rifampin and rifabutin may decrease plasma concentrations and effectiveness of hydantoins by inducing their CYP450 hepatic metabolism.

MANAGEMENT: Close observation for clinical and laboratory evidence of altered hydantoin effect is recommended. Patients should be advised to notify their physician if they experience loss of seizure control. Dosage should be increased as necessary.

References (3)
  1. Venkatesan K (1992) "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet, 22, p. 47-65
  2. Abajo FJ (1988) "Phenytoin interaction with rifampicin." Br Med J, 297, p. 1048
  3. Kay L, Kampmann JP, Svedsen L, et al. (1985) "Influence of rifampicin and isoniazid on the kinetics of phenytoin." Br J Clin Pharmacol, 20, p. 323-6

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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