Skip to main content

Drug Interactions between fosphenytoin and nitrofurantoin

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

nitrofurantoin fosphenytoin

Applies to: nitrofurantoin and fosphenytoin

MONITOR: One patient experienced seizures and a drop in phenytoin levels while taking concurrent nitrofurantoin. Phenytoin levels rose when nitrofurantoin was discontinued. The mechanism is unknown but may be related to induction of hepatic metabolism by nitrofurantoin. A similar reaction may occur with other hydantoins.

MANAGEMENT: Phenytoin serum concentrations should be monitored during coadministration of these agents. Patients should be advised to promptly report loss of seizure control to their caregiver.

References (1)
  1. Heipertz R, Pilz H (1978) "Interaction of nitrofurantoin with diphenylhydantoin." J Neurol, 218, p. 297-301

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer