Skip to main content

Drug Interactions between fosphenytoin and miconazole

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

miconazole fosphenytoin

Applies to: miconazole and fosphenytoin

MONITOR: Miconazole may increase plasma hydantoin concentrations. Phenytoin toxicity has been reported with concurrent parenteral and oral miconazole. The mechanism may be related to inhibition of hepatic CYP450 2C9, the major metabolic pathway for phenytoin.

MANAGEMENT: If miconazole and hydantoins must be used concomitantly, caution is recommended, as is close observation for clinical and laboratory evidence of altered phenytoin effect. Patients should be advised to notify their physician if they experience symptoms of possible hydantoin toxicity, including drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia.

References (1)
  1. Rolan PE, Somogyi AA, Drew MJ, et al. (1983) "Phenytoin intoxication during treatment with parenteral miconazole." Br Med J (Clin Res Ed), 287, p. 1760

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer