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Drug Interactions between fluvastatin and Heliocare Advanced

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

niacin fluvastatin

Applies to: Heliocare Advanced (niacin) and fluvastatin

MONITOR: Severe myopathy and rhabdomyolysis have been reported with concomitant use of lovastatin and niacin, and may be possible with other HMG-CoA inhibitors such as fluvastatin. The mechanism is unknown.

MANAGEMENT: Patients should be instructed to report symptoms of muscular pain, weakness, or tenderness. If such symptoms occur, creatine kinase should be measured. Fluvastatin and niacin should be discontinued if creatine kinase is elevated or if myopathy is suspected.

References (7)
  1. Reaven P, Witztum JL (1988) "Lovastatin, nicotinic acid, and rhabdomyolysis." Ann Intern Med, 109, p. 597-8
  2. Malloy MJ, Kane JP, Kunitake ST, Tun P (1987) "Complementarity of colestipol, niacin, and lovastatin in treatment of severe familial hypercholesterolemia." Ann Intern Med, 107, p. 616-23
  3. (2001) "Product Information. Lescol (fluvastatin)." Novartis Pharmaceuticals
  4. Deslypere JP (1994) "Clinical implications of the biopharmaceutical properties of fluvastatin." Am J Cardiol, 73, d12-7
  5. Jacobson TA, Amorosa LF (1994) "Combination therapy with fluvastatin and niacin in hypercholesterolemia: a preliminary report on safety." Am J Cardiol, 73, d25-9
  6. Jacobson TA, Chin MM, Fromell GJ, Jokubaitis LA, Amorosa LF (1994) "Fluvastatin with and without niacin for hypercholesterolemia." Am J Cardiol, 74, p. 149-54
  7. Smith HT, Jokubaitis LA, Troendle AJ, Hwang DS, Robinson WT (1993) "Pharmacokinetics of fluvastatin and specific drug interactions." Am J Hypertens, 6, s375-82

Drug and food interactions

Moderate

niacin food

Applies to: Heliocare Advanced (niacin)

GENERALLY AVOID: Ethanol can exacerbate the cutaneous flushing that is a common side effect of niacin. At least one case of delirium and lactic acidosis has been reported with coadministration of these drugs, although data are limited.

MANAGEMENT: Coadministration should probably be discouraged, particularly since chronic consumption of large amounts of alcohol is associated with hyperlipidemia.

References (1)
  1. Schwab RA, Bachhuber BH (1991) "Delirium and lactic acidosis caused by ethanol and niacin coingestion." Am J Emerg Med, 9, p. 363-5
Minor

niacin food

Applies to: Heliocare Advanced (niacin)

A single case has been reported in which cutaneous flushing and tremors were noted in a woman who was taking niacin while wearing a nicotine patch. The mechanism is suspected to be synergistic cutaneous vasodilatory effects. The clinical significance of this possible interaction is not known.

References (1)
  1. Rockwell KA Jr (1993) "Potential interaction between niacin and transdermal nicotine." Ann Pharmacother, 27, p. 1283-8

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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