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Drug Interactions between FluMist Quadrivalent and tezepelumab

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

influenza virus vaccine, live tezepelumab

Applies to: FluMist Quadrivalent (influenza virus vaccine, live) and tezepelumab

GENERALLY AVOID: The administration of live, attenuated viral or bacterial vaccines during tezepelumab therapy has not been evaluated. Increased adverse reactions and decreased or suboptimal immunologic response to vaccines may occur; however, data are not available.

MANAGEMENT: In general, live attenuated vaccines should not be used in patients receiving tezepelumab therapy. Administration of live attenuated vaccines in severely immunocompromised persons is generally considered a contraindication. Current local immunization guidelines and prescribing information for individual vaccines should be consulted for recommendations.

References

  1. Department of Health. National Health Service (2019) Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/655225/Greenbook_chapter_6.pdf
  2. (2021) "Product Information. Tezspire (tezepelumab)." Amgen USA
  3. Public Health Agency of Canada (2023) Immunization of immunocompromised persons: Canadian immunization guide https://www.canada.ca/en/public-health/services/publications/healthy-living/canadian-immunization-guide-part-3-vaccination-specific-populations/page-8-immunization-immunocompromised-p
  4. Advisory Committee on Immunization Practices: Centers for Disease Control and Prevention General Best Practice Guidelines for Immunization: Contraindications and Precautions: https://www.cdc.gov/vaccines/hcp/acip-recs/general-recs/contraindications.html
  5. Australian Government. Department of Health and Aged Care Australian Immunisation Handbook: Vaccination for people who are immunocompromised https://immunisationhandbook.health.gov.au/contents/vaccination-for-special-risk-groups/vaccination-for-people-who-are-immunocompromised
View all 5 references

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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