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Drug Interactions between flumazenil and zolpidem

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

zolpidem flumazenil

Applies to: zolpidem and flumazenil

A case report has suggested that flumazenil may reverse coma and respiratory depression in patients experiencing zolpidem toxicity. Also, a small study has confirmed that flumazenil antagonizes the central effects of zolpidem and has suggested that the interaction may be attributable to pharmacodynamic effects.

References (2)
  1. Lheureux P, Debailleul G, De Witte O, Askenasi R (1990) "Zolpidem intoxication mimicking narcotic overdose: response to flumazenil." Hum Exp Toxicol, 9, p. 105-7
  2. Patat A, Naef MM, Vangessel E, Forster A, Dubruc C, Rosenzweig P (1994) "Flumazenil antagonizes the central effects of zolpidem, an imidazopyridine hypnotic." Clin Pharmacol Ther, 56, p. 430-6

Drug and food interactions

Moderate

zolpidem food

Applies to: zolpidem

GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of zolpidem. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.

ADJUST DOSING INTERVAL: Administration of zolpidem with food may delay the onset of hypnotic effects. In 30 healthy subjects, administration of zolpidem 20 minutes after a meal resulted in decreased mean peak plasma drug concentration (Cmax) and area under the concentration-time curve (AUC) by 25% and 15%, respectively, compared to fasting. The time to reach peak plasma drug concentration (Tmax) was prolonged by 60%, from 1.4 to 2.2 hours.

MANAGEMENT: Patients receiving zolpidem should be advised to avoid the consumption of alcohol. For faster sleep onset, zolpidem should not be administered with or immediately after a meal.

References (2)
  1. (2001) "Product Information. Ambien (zolpidem)." sanofi-aventis
  2. Yamreudeewong W, Henann NE, Fazio A, Lower DL, Cassidy TG (1995) "Drug-food interactions in clinical practice." J Fam Pract, 40, p. 376-84

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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