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Drug Interactions between fluconazole and Osphena

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

fluconazole ospemifene

Applies to: fluconazole and Osphena (ospemifene)

Talk to your doctor before using ospemifene together with fluconazole. Combining these medications may increase the blood levels and effects of ospemifene. This may increase the risk of side effects such as hot flush, blood clots, heart attack, stroke, and breast or endometrial cancer. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

ospemifene food

Applies to: Osphena (ospemifene)

Food significantly increases the absorption of ospemifene. You should take ospemifene with a meal, preferably at the same time each day. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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