Skip to main content

Drug Interactions between fluconazole and Indocin SR

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

indomethacin fluconazole

Applies to: Indocin SR (indomethacin) and fluconazole

MONITOR: Coadministration with fluconazole may alter the plasma concentrations of naproxen and its pharmacologically active metabolite. The proposed mechanism is the fluconazole mediated inhibition of the metabolism of naproxen via CYP450 2C9. The interaction may extend to other nonsteroidal anti-inflammatory drugs (NSAIDs) such as meloxicam, lornoxicam, and diclofenac. However, clinical data evaluating this interaction for all the abovementioned nonsteroidal anti-inflammatory drugs are not available.

MANAGEMENT: Caution is recommended with the concomitant use of NSAIDs with fluconazole. It may be advisable to monitor the pharmacologic response to the NSAID and its adverse effects more closely whenever fluconazole is added to or withdrawn from therapy. Patients should be advised to report possible signs of NSAID-related toxicity such as dizziness, drowsiness, headache, tinnitus, nausea, vomiting, dyspepsia, abdominal pain, diarrhea, or black tarry stools.

References (6)
  1. (2025) "Product Information. Suvexx (naproxen-sumatriptan)." Orion Pharma (UK) Ltd
  2. (2024) "Product Information. Diflucan (fluconazole)." Pfizer U.S. Pharmaceuticals Group, 5327512
  3. (2024) "Product Information. Naprosyn (naproxen)." Atnahs Pharma UK Ltd
  4. (2023) "Product Information. Crysanal (naproxen)." Atnahs Pharma Australia Pty Ltd
  5. (2024) "Product Information. Diflucan (fluconazole)." Pfizer Ltd
  6. (2025) "Product Information. Diflucan (flucONAZOLe)." Pfizer Australia Pty Ltd

Drug and food/lifestyle interactions

Moderate

indomethacin food/lifestyle

Applies to: Indocin SR (indomethacin)

GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.

MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

References (1)
  1. (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer