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Drug Interactions between Florinef and ProAmatine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

fludrocortisone midodrine

Applies to: Florinef (fludrocortisone) and ProAmatine (midodrine)

MONITOR: Although midodrine is often used with fludrocortisone (with or without salt supplementation) for the treatment of orthostatic hypotension, this combination may lead to excessive increases in blood pressure and intraocular pressure. Glaucoma may be aggravated in some patients.

MANAGEMENT: Caution is advised, especially in patients with ocular diseases. Blood pressure and intraocular pressure should be monitored during concomitant use. Prior to initiating treatment with midodrine it may be prudent to decrease the dose of fludrocortisone or decrease the patient's salt intake.

References

  1. (2001) "Product Information. ProAmatine (midodrine)." Roberts Pharmaceutical Corporation

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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