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Drug Interactions between flecainide and methenamine / sodium acid phosphate

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

flecainide sodium acid phosphate (obsolete)

Applies to: flecainide and methenamine / sodium acid phosphate

Agents that acidify the urine enhance the renal elimination of flecainide. The result may be decreased plasma flecainide levels and decreased effectiveness. The antiarrhythmic effectiveness of flecainide should be monitored, and plasma flecainide levels should be checked as appropriate. Also, the risk of flecainide toxicity is increased when an agent that acidifies the urine is discontinued.

References

  1. Hertrampf R, Gundert-Remy U, Beckmann J, et al. "Elimination of flecainide as a function of urinary flow rate and pH." Eur J Clin Pharmacol 41 (1991): 61-3

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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