Can you take Fish Oil with Melatonin Sleep Time Release?
No drug interactions found, but 10 warnings to review for the following 2 drugs:
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Melatonin Sleep Time Release (melatonin/pyridoxine)
Drug interactions
There were no interactions found between Fish Oil and Melatonin Sleep Time Release. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
melatonin Food/Lifestyle
Applies to: Melatonin Sleep Time Release (melatonin / pyridoxine)
Both smoking and excessive caffeine consumption can alter the blood levels of melatonin, which may affect the dosing. Tobacco smoking reduces, while caffeine increases melatonin blood levels. If you start smoking or undergo smoking cessation, your doctor may need to adjust the dose of melatonin. In addition, alcohol may reduce the effect of melatonin on sleep. It is best to avoid alcohol consumption during melatonin therapy. Talk to a healthcare professional if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
9 potential interactions Applies to: 8 conditions, including Depression, Arrhythmia, Urinary Retention, Liver Disease, and Cirrhosis.
Alcoholism
Moderate:
Melatonin Sleep Time Release
The pyridoxine in Melatonin Sleep Time Release has a moderate potential interaction with Alcoholism.
The B vitamins are readily absorbed in the GI tract following oral administration. However, GI absorption may be decreased in patients with malabsorption syndromes and other conditions. For example, the absorption of thiamine and pyridoxine may commonly be decreased in alcoholics and in patients with cirrhosis. Likewise, riboflavin absorption may be impaired in patients with hepatitis, cirrhosis, or biliary obstruction. When malabsorption of these vitamins is suspected, parenteral administration may be appropriate.
Arrhythmia
Moderate:
Fish Oil
The omega-3 polyunsaturated fatty acids in Fish Oil has a moderate potential interaction with Arrhythmia.
Cases of recurrent atrial fibrillation (AF) or flutter have been reported with the use of omega-3 fatty acids in patients with a symptomatic paroxysmal AF or persistent AF. This condition is more apparent within the first 2 to 3 months after the initiation of therapy. Therapy with these agents should be administered cautiously in patients with cardiac conduction disorders.
Cirrhosis
Moderate:
Melatonin Sleep Time Release
The pyridoxine in Melatonin Sleep Time Release has a moderate potential interaction with Cirrhosis.
The B vitamins are readily absorbed in the GI tract following oral administration. However, GI absorption may be decreased in patients with malabsorption syndromes and other conditions. For example, the absorption of thiamine and pyridoxine may commonly be decreased in alcoholics and in patients with cirrhosis. Likewise, riboflavin absorption may be impaired in patients with hepatitis, cirrhosis, or biliary obstruction. When malabsorption of these vitamins is suspected, parenteral administration may be appropriate.
Depression
Major:
Melatonin Sleep Time Release
The melatonin in Melatonin Sleep Time Release has a major potential interaction with Depression.
A variety of abnormal thinking and behavior changes have been reported to occur in association with the use of most anxiolytics, sedatives and hypnotics. Some of these changes include decreased inhibition, aggressiveness, agitation, and hallucinations. These drugs can cause or exacerbate mental depression and cause suicidal behavior and ideation. Therapy with these drugs should be administered cautiously in patients with a history of depression or other psychiatric disorders. Patients should be monitored for any changes in mood or behavior. It may be prudent to refrain from dispensing large quantities of medication to these patients.
Glaucoma/Intraocular Hypertension
Moderate:
Melatonin Sleep Time Release
The melatonin in Melatonin Sleep Time Release has a moderate potential interaction with Glaucoma/Intraocular Hypertension.
Some hypnotic drugs can have an anticholinergic effect and should be used with caution in patients with glaucoma, and trouble urinating due to retention or enlarged prostate.
Liver Disease
Moderate:
Fish Oil
The omega-3 polyunsaturated fatty acids in Fish Oil has a moderate potential interaction with Liver Disease.
Increases in alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) levels have been observed in patients receiving omega-3 fatty acids. Therapy with omega-3 fatty acid preparations should be administered cautiously in patients with hepatic impairment. Serum liver enzyme levels should be monitored periodically.
Moderate:
Melatonin Sleep Time Release
The melatonin in Melatonin Sleep Time Release has a moderate potential interaction with Liver Disease.
In general, anxiolytics, sedatives and hypnotics are extensively metabolized by the liver. Their plasma clearance may be decreased and their half-life prolonged in patients with impaired hepatic function. Therapy with these drugs should be administered cautiously in patients with liver disease (some are not recommended in severe liver impairment), and the dosage should be adjusted accordingly. Laboratory testing is recommended prior and during treatment.
Malabsorption Syndrome
Moderate:
Melatonin Sleep Time Release
The pyridoxine in Melatonin Sleep Time Release has a moderate potential interaction with Malabsorption Syndrome.
The B vitamins are readily absorbed in the GI tract following oral administration. However, GI absorption may be decreased in patients with malabsorption syndromes and other conditions. For example, the absorption of thiamine and pyridoxine may commonly be decreased in alcoholics and in patients with cirrhosis. Likewise, riboflavin absorption may be impaired in patients with hepatitis, cirrhosis, or biliary obstruction. When malabsorption of these vitamins is suspected, parenteral administration may be appropriate.
Urinary Retention
Moderate:
Melatonin Sleep Time Release
The melatonin in Melatonin Sleep Time Release has a moderate potential interaction with Urinary Retention.
Some hypnotic drugs can have an anticholinergic effect and should be used with caution in patients with glaucoma, and trouble urinating due to retention or enlarged prostate.
More resources
Fish Oil
A total of 79 drugs are known to interact with Fish Oil.
- Fish oil is in the drug class nutraceutical products.
- Fish oil is used to treat Dietary Supplementation.
Melatonin Sleep Time Release
A total of 359 drugs are known to interact with Melatonin Sleep Time Release.
- Melatonin sleep time release is in the drug class miscellaneous anxiolytics, sedatives and hypnotics.
- Melatonin sleep time release is used to treat Insomnia.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.