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Drug Interactions between Ferretts IPS and Multitrace-4 Pediatric

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

zinc sulfate iron protein succinylate

Applies to: Multitrace-4 Pediatric (trace elements) and Ferretts IPS (iron protein succinylate)

Iron and zinc may reduce each other's absorption when they are coadministered orally. The mechanism of interaction is unknown. In clinical studies, concurrent supplementation with iron and zinc was associated with reduced efficacy in improving the growth and iron and zinc status of malnourished infants compared to supplementation with either one alone. It is not known whether the interaction occurs in adults. In any case, the clinical significance is probably minimal in healthy individuals. However, monitoring for reduced therapeutic response may be advisable in malnourished patients. Limited data suggest that the magnitude of the interaction may be lessened by separating the times of administration of each by 12 hours.

References

  1. Lind T, Lonnerdal B, Stenlund H, et al. "A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: interactions between iron and zinc." Am J Clin Nutr 77 (2003): 883-90
  2. Sreedhar B "Conflicting evidence of iron and zinc interactions in humans: does iron affect zinc absorption?" Am J Clin Nutr 78 (2003): 1226; author reply 1226-7

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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