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Drug Interactions between famotidine and Juluca

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs


famotidine rilpivirine

Applies to: famotidine and Juluca (dolutegravir / rilpivirine)

By reducing the acidity level in the stomach, famotidine can decrease the absorption and blood levels of rilpivirine and make the medication less effective against HIV. To minimize the risk of interaction, famotidine should be taken at least 12 hours before or 4 hours after you take rilpivirine. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions


rilpivirine food

Applies to: Juluca (dolutegravir / rilpivirine)

Food significantly increases the absorption of rilpivirine. You should take each dose of rilpivirine with a meal. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication. Grapefruit juice can also increase the absorption of rilpivirine and should preferably be avoided.

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dolutegravir food

Applies to: Juluca (dolutegravir / rilpivirine)

Information for this minor interaction is available on the professional version.


famotidine food

Applies to: famotidine

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.