Can you take Ezetimibe with Krystexxa?
No drug interactions found, but 3 warnings to review for the following 2 drugs:
- ezetimibe
- Krystexxa (pegloticase)
Drug interactions
There were no interactions found between ezetimibe and Krystexxa. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Food/lifestyle interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease interactions
3 potential interactions Applies to: 3 conditions, including Heart Failure, Liver Disease, and G-6-PD Deficiency.
G-6-PD Deficiency
Major:
Krystexxa
The pegloticase in Krystexxa has a major potential interaction with G-6-PD Deficiency.
The antihyperuricemic agents pegloticase and rasburicase are contraindicated in patients deficient in glucose-6-phosphate-dehydrogenase (G6PD), as these have shown to cause severe hemolytic reactions and methemoglobinemia. Patients at high risk of G6PD deficiency such as patients of African, Mediterranean or Southern Asian ancestry, should be screened prior to starting treatment. Treatment with any of these drugs should be discontinued immediately and permanently in any patient developing hemolysis or methemoglobinemia.
Heart Failure
Moderate:
Krystexxa
The pegloticase in Krystexxa has a moderate potential interaction with Heart Failure.
Pegloticase has not been formally studied in patients with congestive heart failure, and some patients in clinical trials have experienced exacerbation. Caution should be exercised when using pegloticase in these patients and close monitoring following the infusion is recommended.
Liver Disease
Major:
ezetimibe
Ezetimibe has a major potential interaction with Liver Disease.
Ezetimibe is not recommended for use in patients with moderate to severe hepatic impairment (Child-Pugh B or C) due to the unknown effects of increased exposure in this population.
Report options
More resources
ezetimibe
A total of 73 drugs are known to interact with ezetimibe.
- Ezetimibe is in the drug class cholesterol absorption inhibitors.
- Ezetimibe is used to treat the following conditions:
Krystexxa
A total of 34 drugs are known to interact with Krystexxa.
- Krystexxa is in the drug class antihyperuricemic agents.
- Krystexxa is used to treat Gout.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.