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Drug Interactions between Evalose and sodium bicarbonate

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

sodium bicarbonate lactulose

Applies to: sodium bicarbonate and Evalose (lactulose)

Preliminary data from studies in humans and rats suggest that nonabsorbable antacids given concurrently with lactulose may inhibit the reduction in colonic pH induced by lactulose. Theoretically, this may reduce the effectiveness of lactulose in the treatment of portal-systemic encephalopathy, which requires an acidic environment in the colon to promote extraction of ammonia from the blood as well as retention/elimination of ammonia as the ammonium ion. However, the clinical relevance of this interaction has not been fully elucidated.

References

  1. "Product Information. Chronulac (lactulose)." Hoechst Marion Roussel PROD (2002):
  2. "Product Information. Cephulac (lactulose)." Hoechst Marion Roussel PROD (2002):

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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