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Drug Interactions between esomeprazole and obeticholic acid

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

esomeprazole obeticholic acid

Applies to: esomeprazole and obeticholic acid

Coadministration with obeticholic acid may increase the plasma concentrations of omeprazole. The mechanism of interaction has not been described. Omeprazole is primarily metabolized by CYP450 2C19 and 3A4; however, obeticholic acid is not expected to significantly inhibit these pathways at recommended dosages. When a single 20 mg dose of omeprazole was administered with obeticholic acid 10 mg once daily, omeprazole peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 33% and 32%, respectively. The clinical significance is unknown. Conversely, the AUC of obeticholic acid increased by less than 20%, which is not considered clinically relevant. The effect of omeprazole 40 mg once daily with obeticholic acid 10 mg once daily was not studied.

References (1)
  1. (2016) "Product Information. Ocaliva (obeticholic acid)." Intercept Pharmaceuticals, Inc.

Drug and food interactions

Moderate

esomeprazole food

Applies to: esomeprazole

ADJUST DOSING INTERVAL: Food may interfere with the absorption of esomeprazole. The manufacturer reports that the area under the concentration-time curve for esomeprazole following a single 40 mg dose was 33% to 53% lower when administered after food intake as opposed to during fasting conditions.

MANAGEMENT: Esomeprazole should be taken at least one hour before meals. When administered to patients receiving continuous enteral nutrition, some experts recommend that the tube feeding should be interrupted for at least 1 hour before and 1 hour after the dose of esomeprazole is given.

References (2)
  1. (2001) "Product Information. Nexium (esomeprazole)." Astra-Zeneca Pharmaceuticals
  2. Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT (2009) "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm, 66, p. 1438-67

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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