Drug Interactions between eplerenone and Opium Tincture, Deodorized
This report displays the potential drug interactions for the following 2 drugs:
- eplerenone
- Opium Tincture, Deodorized (opium)
Interactions between your drugs
opium eplerenone
Applies to: Opium Tincture, Deodorized (opium) and eplerenone
Consumer information for this interaction is not currently available.
MONITOR: Opioids exhibit hypotensive effects, especially during initiation of therapy and dose escalation. Coadministration with diuretics may lead to an increased risk of hypotension. In contrast, opioids may also decrease the efficacy of diuretics as they may trigger the secretion of antidiuretic hormone, although the proposed mechanism for this interaction is unclear and clinical studies are not currently available.
MANAGEMENT: Caution and close monitoring for development of hypotension in addition to decreased diuretic efficacy are advised during coadministration of these agents. Blood pressure should be monitored throughout therapy and dose adjustment of the diuretic should be considered. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia. Patients should also avoid driving or operating hazardous machinery until they know how the medications affect them.
Drug and food/lifestyle interactions
eplerenone food/lifestyle
Applies to: eplerenone
Consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit should be avoided during treatment with eplerenone as they may increase the blood levels and effects of eplerenone. High blood levels of eplerenone can increase the risk of side effects including hyperkalemia (high blood potassium), which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. You may be more likely to develop hyperkalemia during treatment with eplerenone if you are elderly, dehydrated, or have kidney disease, diabetes, or advanced heart failure. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, as these may be symptoms of hyperkalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
opium food/lifestyle
Applies to: Opium Tincture, Deodorized (opium)
Do not use alcohol or medications that contain alcohol while you are receiving treatment with opium. This may increase nervous system side effects such as drowsiness, dizziness, lightheadedness, difficulty concentrating, and impairment in thinking and judgment. In severe cases, low blood pressure, respiratory distress, fainting, coma, or even death may occur. With certain long-acting formulations of narcotic pain medication, consumption of alcohol may also cause rapid release of the drug, resulting in high blood levels that may be potentially lethal. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. Do not use more than the recommended dose of opium, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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