Can you take Ensartinib with Freeze It?
1 drug interaction and 7 additional warnings found for the following 2 drugs:
- ensartinib
- Freeze It (camphor/menthol topical)
Drug interactions
Minor drug interactions
Minor:
menthol topical ensartinib
Applies to: Freeze It (camphor / menthol topical) and ensartinib
Information for this minor interaction is available on the professional version.
Food/lifestyle interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease interactions
7 potential interactions Applies to: 7 conditions, including Allergies, Asthma, Liver Disease, Interstitial Lung Disease, and Visual Defect/Disturbance.
Allergies
Major:
ensartinib
Ensartinib has a major potential interaction with Allergies.
Ensartinib contains FD&C Yellow 5 (tartrazine) and may cause allergic-type reactions, including bronchial asthma, in susceptible persons. These reactions are frequently seen in patients who also have hypersensitivity to aspirin. This drug is contraindicated in persons who experienced previous hypersensitivity reactions to the active ingredient or any of the excipients.
Asthma
Major:
ensartinib
Ensartinib has a major potential interaction with Asthma.
Ensartinib contains FD&C Yellow 5 (tartrazine) and may cause allergic-type reactions, including bronchial asthma, in susceptible persons. These reactions are frequently seen in patients who also have hypersensitivity to aspirin. This drug is contraindicated in persons who experienced previous hypersensitivity reactions to the active ingredient or any of the excipients.
Interstitial Lung Disease
Moderate:
ensartinib
Ensartinib has a moderate potential interaction with Interstitial Lung Disease.
Ensartinib can cause severe interstitial lung disease (ILD)/pneumonitis. Monitor patients on ensartinib for new or worsening symptoms indicative of ILD/pneumonitis (e.g., dyspnea, cough, and fever) during treatment. Immediately withhold therapy in patients with suspected ILD/pneumonitis; permanently discontinue if confirmed.
Liver Disease
Moderate:
ensartinib
Ensartinib has a moderate potential interaction with Liver Disease.
Ensartinib should be avoided in patients with severe liver dysfunction (total bilirubin greater than 3 x ULN and any AST). Monitor patients with moderate liver dysfunction (total bilirubin greater than 1.5 to 3 x ULN and any AST) for increased adverse reactions and adjust dosage as indicated. No dose adjustment is recommended in patients with mild liver dysfunction. Additionally, ensartinib may cause hepatotoxicity, including drug-induced liver injury. Monitor liver function tests including ALT, AST, and total bilirubin at baseline and every 2 weeks during the first treatment cycle, and then monthly or as indicated.
Pulmonary Impairment
Moderate:
ensartinib
Ensartinib has a moderate potential interaction with Pulmonary Impairment.
Ensartinib can cause severe interstitial lung disease (ILD)/pneumonitis. Monitor patients on ensartinib for new or worsening symptoms indicative of ILD/pneumonitis (e.g., dyspnea, cough, and fever) during treatment. Immediately withhold therapy in patients with suspected ILD/pneumonitis; permanently discontinue if confirmed.
Renal Dysfunction
Moderate:
ensartinib
Ensartinib has a moderate potential interaction with Renal Dysfunction.
The effect of severe renal dysfunction or end-stage renal disease (with or without hemodialysis) on the pharmacokinetics (PK) of ensartinib is unknown. No clinically significant PK differences were observed based on mild or moderate renal dysfunction.
Visual Defect/Disturbance
Moderate:
ensartinib
Ensartinib has a moderate potential interaction with Visual Defect/Disturbance.
Ensartinib can cause visual disturbances. Obtain an ophthalmologic evaluation in patients with new or worsening visual symptoms during treatment. Withhold, reduce the dose, or permanently discontinue based on severity visual adverse effects.
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More resources
ensartinib
A total of 283 drugs are known to interact with ensartinib.
- Ensartinib is in the drug class multikinase inhibitors.
- Ensartinib is used to treat Non Small Cell Lung Cancer.
Freeze It
A total of 364 drugs are known to interact with Freeze It.
- Freeze it is in the drug class topical rubefacient.
- Freeze it is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.