Drug Interactions between elagolix / estradiol / norethindrone and pralsetinib

Elagolix may significantly reduce the blood levels of pralsetinib, which may make the medication less effective in treating your cancer. Your doctor(s) may be able to prescribe alternatives that do not interact. However, they may already be aware of the risks, but determined that this is the best course of treatment for you and have taken appropriate precautions, such as adjusting the dose of pralsetinib and/or monitoring you closely for any potential complications. Talk to your doctor if you have any questions or concerns. You should seek immediate medical attention if you experience side effects such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, or yellowing of the skin or eyes during treatment with these medications, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Estradiol and other estrogen-containing medications may reduce the effectiveness of elagolix in treating your condition. If you require contraception, it is recommended that you use a non-hormonal form of contraception during treatment with elagolix and for one week after its discontinuation. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Pralsetinib may alter the blood levels and effects of estradiol. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Elagolix may reduce the blood levels and effects of norethindrone. If you are using low-dose oral contraceptives, you may have an increased risk of breakthrough bleeding and unintended pregnancy. You should discuss the use of alternative or additional methods of birth control with your healthcare provider. If you take hormone replacement for menopause, notify your doctor if your medication is no longer controlling your symptoms or you experience abnormal bleeding. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Pralsetinib may reduce the blood levels and effectiveness of norethindrone, which may make it less reliable as a form of birth control. To avoid unintended pregnancy, females of reproductive potential receiving pralsetinib and their male partners should be advised to use alternative or additional methods of birth control such as condoms during treatment with pralsetinib and for 2 weeks after stopping treatment. Talk to your gynecologist or other healthcare professional for help in selecting an effective method of birth control that is best for you. Men receiving pralsetinib with female partners of reproductive potential should also use alternative or additional methods of birth control such as a condom during the treatment period and for 1 week after stopping treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.