Drug Interactions between elagolix / estradiol / norethindrone and isotretinoin

Estradiol and other estrogen-containing medications may reduce the effectiveness of elagolix in treating your condition. If you require contraception, it is recommended that you use a non-hormonal form of contraception during treatment with elagolix and for one week after its discontinuation. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Using ISOtretinoin and norethindrone is not recommended. ISOtretinoin can cause severe, life-threatening birth defects if the mother takes the medication during pregnancy. Even one dose of ISOtretinoin can cause major birth defects of the baby's ears, eyes, face, skull, heart, and brain. Never use ISOtretinoin if you are pregnant. You must agree in writing to use two specific forms of birth control beginning 30 days before you start taking ISOtretinoin and ending 30 days after you stop taking it. Both a primary and a secondary form of birth control must be used together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Elagolix may reduce the blood levels and effects of norethindrone. If you are using low-dose oral contraceptives, you may have an increased risk of breakthrough bleeding and unintended pregnancy. You should discuss the use of alternative or additional methods of birth control with your healthcare provider. If you take hormone replacement for menopause, notify your doctor if your medication is no longer controlling your symptoms or you experience abnormal bleeding. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.