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Drug Interactions between Effexor XR and vasopressin

This report displays the potential drug interactions for the following 2 drugs:

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Moderate

vasopressin venlafaxine

Applies to: vasopressin and Effexor XR (venlafaxine)

MONITOR: The antidiuretic response to vasopressin or desmopressin may be potentiated by certain drugs, including nonsteroidal anti-inflammatory agents, selective serotonin reuptake inhibitors, tricyclic/tetracyclic antidepressants, carbamazepine, chlorpropamide, chlorpromazine, clofibrate, eslicarbazepine, fludrocortisone, haloperidol, lamotrigine, oxcarbazepine, urea, and some antineoplastic agents (e.g., vinca alkaloids, cisplatin, cyclophosphamide). These drugs can occasionally cause fluid retention, in some cases secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Coadministration with vasopressin or desmopressin may, therefore, increase the risk of water intoxication and/or hyponatremia. Seizure and coma in association with severe hyponatremia have been reported during concomitant use of desmopressin and imipramine or ibuprofen. In addition, indomethacin may prolong the effects of vasopressin on cardiac index and systemic vascular resistance. The elderly may be particularly susceptible.

MANAGEMENT: Caution is advised when vasopressin or desmopressin is used in combination with drugs that can cause fluid retention or SIADH. Some authorities recommend adjusting vasopressin dosage as needed. Serum electrolytes, especially sodium, as well as BUN and creatinine should be monitored regularly. Patients should be advised to seek medical attention if they develop signs and symptoms of water intoxication or hyponatremia such as anorexia, nausea, vomiting, headache, malaise, lethargy, irritability, difficulty concentrating, memory impairment, confusion, weakness, muscle spasm, unsteadiness (which may lead to falls), anuria, and weight gain. Severe hyponatremia can be life-threatening if it is not promptly diagnosed and treated; therefore, early treatment is important to help prevent progression to seizures, coma, respiratory arrest, and death.

References (181)
  1. Lahr MB (1985) "Hyponatremia during carbamazepine therapy." Clin Pharmacol Ther, 37, p. 693-6
  2. Kalff R, Houtkooper MA, Meyer JW, et al. (1984) "Carbamazepine and serum sodium levels." Epilepsia, 24, p. 390-7
  3. Epstein S, Van Mieghem W, Simson E, Jackson WP (1972) "Chlorpropamide hyponatremia." N Engl J Med, 286, p. 785
  4. Aasen G, Frey HM (1980) "Excessive sensitivity to the hyponatremic effect of chlorpropamide in a patient with diabetes mellitus and anterior pituitary insufficiency." Acta Med Scand, 208, p. 233-6
  5. Tanay A, Firemann Z, Yust I, Abramov AL (1981) "Chlorpropamide-induced syndrome of inappropriate antidiuretic hormone secretion." J Am Geriatr Soc, 29, p. 334-6
  6. Sloan RW, Kreider RM, Luderer JR (1983) "The effect of chlorpropamide hyponatremia on mental status in a nursing home population." J Fam Pract, 16, p. 937-42
  7. Kadowaki T, Hagura R, Kajinuma H, et al. (1983) "Chlorpropamide-induced hyponatremia: incidence and risk factors." Diabetes Care, 6, p. 468-71
  8. Webberley MJ, Murray JA (1989) "Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin." Postgrad Med J, 65, p. 950-2
  9. Zawada ET (1982) "Renal consequences of nonsteroidal antiinflammatory drugs." Postgrad Med J, 71, p. 223-30
  10. Petersson I, Nilsson G, Hansson B-G, Hedner T (1987) "Water intoxication associated with non-steroidal anti-inflammatory drug therapy." Acta Med Scand, 221, p. 221-3
  11. Appel WC (1987) "Possible roles of normeperidine and hyponatremia in a postoperative death." Can Med Assoc J, 137, p. 912-3
  12. Hamburger S, Langley H, Bowers G (1980) "The syndrome of inappropriate secretion of antidiuretic hormone associated with amitriptyline or trifluoperazine administration." J Kans Med Soc, 81, p. 469-70
  13. Madhusoodanan S, Osnos R (1981) "Amitriptyline induced hyponatremia: a case report." Mt Sinai J Med, 48, p. 431-3
  14. Henkin Y, Kaplan Z, Alkan M (1989) "Psychiatric presentation of hyponatremia associated with the use of amitriptyline: a report of two cases." Isr J Med Sci, 25, p. 587-9
  15. Orbo A, Simonsen E (1992) "Cisplatin-induced sodium and magnesium wastage." Eur J Cancer, 28A, p. 1294
  16. Hwang AS, Magraw RM (1989) "Syndrome of inappropriate secretion of antidiuretic hormone due to fluoxetine." Am J Psychiatry, 146, p. 399
  17. Miller MG (1989) "Tricyclics as a possible cause of hyponatremia in psychiatric patients." Am J Psychiatry, 146, p. 807
  18. Zalin AM, Hutchinson CE, Jong M, Matthews K (1984) "Hyponatraemia during treatment with chlorpropamide and Moduretic (amiloride plus hydrochlorothiazide)." Br Med J (Clin Res Ed), 289, p. 659
  19. Laycock JF, Lewis AF (1977) "Potentiation of the response to vasopressin (pitressin) by treatment with a combination of chlorpropamide and chlorothiazide in Brattleboro rats with hereditary hypothalamic diabetes insipidus." Br J Pharmacol, 59, p. 11-6
  20. Moses AM, Miller M (1974) "Drug-induced dilutional hyponatremia." N Engl J Med, 291, p. 1234-9
  21. DeFronzo RA, Braine H, Colvin M, Davis PJ (1973) "Water intoxication in man after cyclophosphamide therapy: time course and relation to drug activation." Ann Intern Med, 78, p. 861-9
  22. Lichtigfeld FJ, Gillman MA (1990) "Dangerous synergism between sedatives and a hyponatraemic state." J R Soc Med, 83, p. 185
  23. Abbott R (1983) "Hyponatremia due to antidepressant medications." Ann Emerg Med, 12, p. 708-10
  24. Hamed M, Mitchell H, Clow DJ (1993) "Hyponatraemic convulsion associated with desmopressin and imipramine treatment." BMJ, 306, p. 1169
  25. Parker WA (1984) "Imipramine-induced syndrome of inappropriate antidiuretic hormone secretion." Drug Intell Clin Pharm, 18, p. 890-4
  26. Mitsch RA, Lee AK (1986) "Syndrome of inappropriate antidiuretic hormone with imipramine." Drug Intell Clin Pharm, 20, p. 787-9
  27. Vishwanath BM, Navalgund AA, Cusano W, Navalgund KA (1991) "Fluoxetine as a cause of SIADH." Am J Psychiatry, 148, p. 542-3
  28. Staab JP, Yerkes SA, Cheney EM, Clayton AH (1990) "Transient SIADH associated with fluoxetine." Am J Psychiatry, 147, p. 1569-70
  29. Cohen BJ, Mahelsky M, Adler L (1990) "More cases of SIADH with fluoxetine." Am J Psychiatry, 147, p. 948-9
  30. Kazal LA, Jr Hall DL, Miller LG, Noel ML (1993) "Fluoxetine-induced SIADH: a geriatric occurrence?" J Fam Pract, 36, p. 341-3
  31. Rault RM (1993) "Case report: hyponatremia associated with nonsteroidal antiinflammatory drugs." Am J Med Sci, 305, p. 318-20
  32. Cheung NT, Coley S, Sheeran T, Situnayake RD (1993) "Syndrome of inappropriate secretion of antidiuretic hormone induced by diclofenac." BMJ, 306, p. 186
  33. Davison P, Wardrope J (1993) "Acute amitriptyline withdrawal and hyponatraemia. A case report." Drug Saf, 8, p. 78-80
  34. Crews JR, Potts NL, Schreiber J, Lipper S (1993) "Hyponatremia in a patient treated with sertraline." Am J Psychiatry, 150, p. 1564
  35. Blacksten JV, Birt JA (1993) "Syndrome of inappropriate secretion of antidiuretic hormone secondary to fluoxetine." Ann Pharmacother, 27, p. 723-4
  36. Pledger DR, Mathew H (1989) "Hyponatraemia and clomipramine therapy." Br J Psychiatry, 154, p. 263-4
  37. Garson M (1979) "Syndrome of dilutional hyponatraemia secondary to tricyclic antidepressant." Practitioner, 222, p. 411-2
  38. Chua TP, Vong SK (1993) "Hyponatraemia associated with paroxetine." BMJ, 306, p. 143
  39. Goddard C, Paton C (1992) "Hyponatraemia associated with paroxetine." BMJ, 305, p. 1332
  40. Kinzie BJ (1987) "Management of the syndrome of inappropriate secretion of antidiuretic hormone." Clin Pharm, 6, p. 625-33
  41. Colgate R (1993) "Hyponatraemia and inappropriate secretion of antidiuretic hormone associated with the use of imipramine." Br J Psychiatry, 163, p. 819-22
  42. Gandelman MS (1994) "Review of carbamazepine-induced hyponatremia." Prog Neuropsychopharmacol Biol Psychiatry, 18, p. 211-33
  43. Ananth J, Lin KM (1986) "Siadh: a serious side effect of psychotropic drugs." Int J Psychiatry Med, 16, p. 401-7
  44. Matuk F, Kalyanaraman K (1977) "Inappropriate ADH secretion." Arch Neurol, 34, p. 725
  45. Doshi D, Borison R (1994) "Association of transient SIADH with sertraline." Am J Psychiatry, 151, p. 779-80
  46. Kosten TR, Camp W (1980) "Inappropriate secretion of antidiuretic hormone in a patient receiving piperazine phenothiazines." Psychosomatics, 21, 351,354-5
  47. Pillans PI, Coulter DM (1994) "Fluoxetine and hyponatraemia - a potential hazard in the elderly." N Z Med J, 107, p. 85-6
  48. Baliga RR, McHardy KC (1993) "Syndrome of inappropriate antidiuretic hormone secretion due to fluvoxamine therapy [published erratum appears in Br J Clin Pract 1993 May-Jun;47(3):119]." Br J Clin Pract, 47, p. 62-3
  49. Robson WL, Leung AK (1993) "Hyponatraemia following desmopressin." BMJ, 307, p. 64-5
  50. Llorente MD, Gorelick M, Silverman MA (1994) "Sertraline as the cause of inappropriate antidiuretic hormone secretion." J Clin Psychiatry, 55, p. 543-4
  51. (2001) "Product Information. Pitressin (vasopressin)." Parke-Davis
  52. (2001) "Product Information. DDAVP (desmopressin)." Rhone Poulenc Rorer
  53. (2001) "Product Information. Stimate (desmopressin)." Forest Pharmaceuticals
  54. Rider JM, Mauger TF, Jameson JP, Notman DD (1995) "Water handling in patients receiving haloperidol decanoate." Ann Pharmacother, 29, p. 663-6
  55. Thornton SL, Resch DS (1995) "SIADH associated with sertraline therapy." Am J Psychiatry, 152, p. 809
  56. Jackson C, Carson W, Markowitz J, Mintzer J (1995) "SIADH associated with fluoxetine and sertraline therapy." Am J Psychiatry, 152, p. 809-10
  57. Bluff DD, Oji N (1995) "SIADH in a patient receiving sertraline." Ann Intern Med, 123, p. 811
  58. Ayonrinde OT, Reutens SG, Sanfilippo FM (1995) "Paroxetine-induced SIADH." Med J Aust, 163, p. 390
  59. Leung M, Remick R (1995) "Sertraline-associated hyponatremia." Can J Psychiatry, 40, p. 497-8
  60. Cantwell BM, Idle M, Millward MJ, Hall G, Lind MJ (1990) "Encephalopathy with hyponatremia and inappropriate arginine vasopressin secretion following an intravenous ifosfamide infusion." Ann Oncol, 1, p. 232
  61. Culine S, Ghosn M, Droz JP (1990) "Inappropriate antidiuretic hormone secretion induced by ifosfamide." Eur J Cancer, 26, p. 922
  62. el Weshi A, Thieblemont C, Cottin V, Barbet N, Catimel G (1995) "Cisplatin-induced hyponatremia and renal sodium wasting." Acta Oncol, 34, p. 264-5
  63. Bissett D Cornford EJ Sokal M (1989) "Hyponatraemia following cisplatin chemotherapy." Acta Oncol, 28, p. 823
  64. Zavagli G Ricci G Tataranni G Mapelli G Abbasciano V (1988) "Life-threatening hyponatremia caused by vinblastine." Med Oncol Tumor Pharmacother, 5, p. 67-9
  65. Tomiwa K, Mikawa H, Hazama F, Yazawa K, Hosoya R, Ohya T, Nishimura K (1983) "Syndrome of inappropriate secretion of antidiuretic hormone caused by vincristine therapy: a case report of the neuropathology." J Neurol, 229, p. 267-72
  66. Cutting HO (1971) "Inappropriate secretion of antidiuretic hormone secondary to vincristine therapy." Am J Med, 51, p. 269-71
  67. Whittaker JA, Parry DH, Bunch C, Weatherall DJ (1973) "Coma associated with vincristine therapy." Br Med J, 4, p. 335-7
  68. Nicholson RG, Feldman W (1972) "Hyponatremia in association with vincristine therapy." Can Med Assoc J, 106, p. 356-7
  69. Oldham RK, Pomeroy TC (1972) "Vincristine-induced syndrome of inappropriate secretion of antidiuretic hormone." South Med J, 65, p. 1010-2
  70. Flint AJ, Crosby J, Genik JL (1996) "Recurrent hyponatremia associated with fluoxetine and paroxetine." Am J Psychiatry, 153, p. 134
  71. ten Holt WL, van Iperen CE, Schrijver G, Bartelink AK (1996) "Severe hyponatremia during therapy with fluoxetine." Arch Intern Med, 156, p. 681-2
  72. Otsuka F, Hayashi Y, Ogura T, et al. (1996) "Syndrome of inappropriate secretion of antidiuretic hormone following intra-thoracic cisplatin." Intern Med, 35, p. 290-4
  73. Bjorck E, Samuelsson J (1996) "Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) after treatment with cyclophosphamide, alpha-interferon and betamethasone in a patient with multiple myeloma." Eur J Haematol, 56, p. 323-5
  74. Goldstein L, Barker M, Segall F, Asihene R, Balser S, Lautenbach D, Mccoy M (1996) "Seizure and transient SIADH associated with sertraline." Am J Psychiatry, 153, p. 732
  75. Catalano G, Kanfer SN, Catalano MC, Alberts VA (1996) "The role of sertraline in a patient with recurrent hyponatremia." Gen Hosp Psychiatry, 18, p. 278-83
  76. Kessler J, Samuels SC (1996) "Sertraline and hyponatremia." N Engl J Med, 335, p. 524
  77. Bradley ME, Foote EF, Lee EN, Merkle L (1996) "Sertraline-associated syndrome of inappropriate antidiuretic hormone: case report and review of the literature." Pharmacotherapy, 16, p. 680-3
  78. (1996) "Selective serotonin reuptake inhibitors and SIADH." Med J Aust, 164, p. 562
  79. Robinson D, Brooks J, Mahler E, Sheikh JI (1996) "SIADH--compulsive drinking or SSRI influence?" Ann Pharmacother, 30, p. 885
  80. Giles PD, Seem CC (1985) "Dothiepin and water handling." Lancet, 2, p. 1013
  81. Fort S, Bannister P, Manning A, Bolton R, Losowsky MS (1985) "Inappropriate antidiuretic hormone secretion associated with dothiepin." Lancet, 2, p. 551
  82. Wylie KR, Harris SJ, Harrop FM (1989) "Lofepramine-induced hyponatraemia." Br J Psychiatry, 154, p. 419-20
  83. O'Sullivan D, Oyebode F (1987) "Hyponatraemia and lofepramine." Br J Psychiatry, 150, p. 720-1
  84. Schattner A, Skurnik Y (1996) "Fluoxetine-induced SIADH." J Am Geriatr Soc, 44, p. 1413
  85. van Campen JP, Voets AJ (1996) "SIADH caused by paroxetine." Ann Pharmacother, 30, p. 1499
  86. Woo MH, Smythe MA (1997) "Association of SIADH with selective serotonin reuptake inhibitors." Ann Pharmacother, 31, p. 108-10
  87. Bouman WP, Johnson H, TrescoliSerrano C, Jones RG (1997) "Recurrent hyponatremia associated with sertraline and lofepramine." Am J Psychiatry, 154, p. 580
  88. Girault C, Richard JC, Chevron V, Goulle JP, Droy JM, Bonmarchand G, Leroy J (1997) "Syndrome of inappropriate secretion of antidiuretic hormone in two elderly women with elevated serum fluoxetine." J Toxicol Clin Toxicol, 35, p. 93-5
  89. John L, Perreault MM, Tao T, Blew PG (1997) "Serotonin syndrome associated with nefazodone and paroxetine." Ann Emerg Med, 29, p. 287-9
  90. Lane RM (1997) "SSRIs and hyponatraemia." Br J Clin Pract, 51, p. 144-6
  91. Gupta AK, Saravay SM (1997) "Venlafaxine-induced hyponatremia." J Clin Psychopharmacol, 17, p. 223-5
  92. Meynaar IA, Peeters AJ, Mulder AH, Ottervanger JP (1997) "Syndrome of inappropriate ADH secretion attributed to the serotonin re-uptake inhibitors, venlafaxine and paroxetine." Neth J Med, 50, p. 243-5
  93. Ayonrinde OT, Sanfilippo FM (1997) "SSRI antidepressants and SIADH." Aust N Z J Psychiatry, 31, p. 306-7
  94. Liu BA, Mittmann N, Knowles SR, Shear NH (1996) "Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone associated with the use of selective serotoni reuptake inhibitors: a review of spontaneous reports [publishe erratum appears in Can Med Assoc J 1996 Oct 15;155(8):1043." CMAJ, 155, p. 519-27
  95. Levsky ME, Schwartz JB (1998) "Sertraline-induced hyponatremia in an older patient." J Am Geriat Soc, 46, p. 1582-3
  96. Garrett CA, Simpson TA (1998) "Syndrome of inappropriate antidiuretic hormone associated with vinorelbine therapy." Ann Pharmacother, 32, p. 1306-9
  97. Boyd IW (1998) "Hyponatremia with venlafaxine." Ann Pharmacother, 32, p. 981
  98. Masood GR, Karki SD, Patterson WR (1998) "Hyponatremia with venlafaxine." Ann Pharmacother, 32, p. 49-51
  99. Van Amelsvoort T, Bakshi R, Devaux CB, Schwabe S (1994) "Hyponatremia associated with carbamazepine and oxcarbazepine therapy: a review." Epilepsia, 35, p. 181-8
  100. Steinhoff BJ, Stoll KD, Stodieck SR, Paulus W (1992) "Hyponatremic coma under oxcarbazepine therapy." Epilepsy Res, 11, p. 67-70
  101. Nielsen OA, Johannessen AC, Bardrum B (1988) "Oxcarbazepine-induced hyponatremia, a cross-sectional study." Epilepsy Res, 2, p. 269-71
  102. Johannessen AC, Nielsen OA (1987) "Hyponatremia induced by oxcarbazepine." Epilepsy Res, 1, p. 155-6
  103. Settle EC (1998) "Antidepressant drugs: disturbing and potentially dangerous adverse effects." J Clin Psychiatry, 59 Suppl 16, p. 25-30
  104. Ryan M, Adams AG, Larive LL (2001) "Hyponatremia and leukopenia associated with oxcarbazepine following carbamazepine therapy." Am J Health Syst Pharm, 58, p. 1637-9
  105. Woster P, Carrazana EJ (2002) "Oxcarbazepine and hyponatremia." Am J Health Syst Pharm, 59, p. 467
  106. Harris RC (2002) "Cyclooxygenase-2 inhibition and renal physiology." Am J Cardiol, 89(6 Suppl 1), p. 10-7
  107. Cilli AS, Algun E (2002) "Oxcarbazepine-induced syndrome of inappropriate secretion of antidiuretic hormone." J Clin Psychiatry, 63, p. 742
  108. Izzedine H, Launay-Vacher V, Ciroldi M, Fardet L, Deray G (2002) "Fanconi and inappropriate secretion of antidiuretic hormone syndromes secondary to venlafaxine therapy." Nephron, 92, p. 944-6
  109. Shang CY, Soong WT, Lin HN (2002) "Hypokalemia with venlafaxine." J Clin Psychiatry, 63, p. 1049-50
  110. Kokko H, Hall PD, Afrin LB (2002) "Fentanyl-associated syndrome of inappropriate antidiuretic hormone secretion." Pharmacotherapy, 22, p. 1188-92
  111. Roxanas MG (2003) "Mirtazapine-induced hyponatraemia." Med J Aust, 179, p. 453-4
  112. Degner D, Grohmann R, Kropp S, et al. (2004) "Severe adverse drug reactions of antidepressants: results of the German multicenter drug surveillance program AMSP." Pharmacopsychiatry, 37 Suppl 1, S39-45
  113. Kuz GM, Manssourian A (2005) "Carbamazepine-induced hyponatremia: assessment of risk factors." Ann Pharmacother, 39, p. 1943-6
  114. Dong X, Leppik IE, White J, Rarick J (2005) "Hyponatremia from oxcarbazepine and carbamazepine." Neurology, 65, p. 1976-8
  115. Maramattom BV (2006) "Duloxetine-induced syndrome of inappropriate antidiuretic hormone secretion and seizures." Neurology, 66, p. 773-4
  116. Davis FB, Davis PJ (1981) "Water metabolism in diabetes mellitus." Am J Med, 70, p. 210-4
  117. Moses AM, Howanitz J, Miller M (1973) "Diuretic action of three sulfonylurea drugs." Ann Intern Med, 78, p. 541-4
  118. Garcia M, Miller M, Moses AM (1971) "Chlorpropamide-induced water retention in patients with diabetes mellitus." Ann Intern Med, 75, p. 549-54
  119. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  120. Egger C, Muehlbacher M, Nickel M, Geretsegger C, Stuppaeck C (2006) "A case of recurrent hyponatremia induced by venlafaxine." J Clin Psychopharmacol, 26, p. 439
  121. Jacob S, Spinler SA (2006) "Hyponatremia associated with selective serotonin-reuptake inhibitors in older adults." Ann Pharmacother, 40, p. 1618-22
  122. Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
  123. Bavbek N, Kargili A, Akcay A, Kaya A (2006) "Recurrent hyponatremia associated with citalopram and mirtazapine." Am J Kidney Dis, 48, e61-2
  124. Safdieh JE, Rudominer R (2006) "A case of hyponatremia induced by duloxetine." J Clin Psychopharmacol, 26, p. 675-676
  125. Kruger S, Lindstaedt M (2007) "Duloxetine and hyponatremia: a report of 5 cases." J Clin Psychopharmacol, 27, p. 101-104
  126. Dirks AC, van Hyfte DM (2007) "Recurrent hyponatremia after substitution of citalopram with duloxetine." J Clin Psychopharmacol, 27, p. 313
  127. Kuroda H, Kawamura M, Hato T, et al. (2007) "Syndrome of inappropriate secretion of antidiuretic hormone after chemotherapy with vinorelbine." Cancer Chemother Pharmacol
  128. Ljung R (2008) "Use of desmopressin and concomitant use of potentially interacting drugs in elderly patients in Sweden." Eur J Clin Pharmacol
  129. Cerner Multum, Inc. "Australian Product Information."
  130. Kosmidis HV, Bouhoutsou DO, Varvoutsi MC, et al. (1991) "Vincristine overdose: experience with 3 patients." Pediatr Hematol Oncol, 8, p. 171-8
  131. Draper B, Berman K (2008) "Tolerability of selective serotonin reuptake inhibitors: issues relevant to the elderly." Drugs Aging, 25, p. 501-19
  132. Sarret D, Le Berre JP, Zemraoui N (2008) "Tramadol-induced hyponatremia." Am J Kidney Dis, 52, 1026; author reply 1027
  133. Ortenzi A, Paggi A, Foschi N, Sabbatini D, Pistoli E (2008) "Oxcarbazepine and adverse events: impact of age, dosage, metabolite serum concentrations and concomitant antiepileptic therapy." Funct Neurol, 23, p. 97-100
  134. Famularo G, Gasbarrone L, De Virgilio A, Minisola G (2009) "Mirtazapine-associated hyponatremia in an elderly patient." Ann Pharmacother, 43, p. 1144-5
  135. Weir MR (2002) "Renal effects of nonselective NSAIDs and coxibs." Cleve Clin J Med, 69(Suppl 1), SI53-8
  136. (1986) "Non-steroidal anti-inflammatory drugs and the kidney." Br Med J (Clin Res Ed), 293, p. 202-3
  137. Palmer BF, Gates JR, Lader M (2003) "Causes and management of hyponatremia." Ann Pharmacother, 37, p. 1694-702
  138. Twardowschy CA, Bertolucci CB, Gracia Cde M, Brandao MA (2006) "Severe hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with fluoxetine: case report." Arq Neuropsiquiatr, 64, p. 142-5
  139. Schwab M, Roder F, Morike K, Thon KP, Klotz U (1999) "Drug-induced hyponatraemia in elderly patients." Br J Clin Pharmacol, 48, p. 105-6
  140. Purcell P, Valmana A (1996) "Toxic epidermal necrolysis following chlorpromazine ingestion complicated by SIADH." Postgrad Med J, 72, p. 186-9
  141. Wilkinson TJ, Begg EJ, Winter AC, Sainsbury R (1999) "Incidence and risk factors for hyponatraemia following treatment with fluoxetine or paroxetine in elderly people." Br J Clin Pharmacol, 47, p. 211-7
  142. Matsumura M, Yamaguchi M, Sato T (2001) "Severe hyponatremia in a patient treated with levomepromazine and carbamazepine." Intern Med, 40, p. 459
  143. Isojarvi JI, Huuskonen UE, Pakarinen AJ, Vuolteenaho O, Myllyla VV (2001) "The regulation of serum sodium after replacing carbamazepine with oxcarbazepine." Epilepsia, 42, p. 741-5
  144. Stephens WP, Coe JY, Baylis PH (1978) "Plasma arginine vasopressin concentrations and antidiuretic action of carbamazepine." Br Med J, 1, p. 1445-7
  145. Smith NJ, Espir ML, Baylis PH (1977) "Raised plasma arginine vasopressin concentration in carbamazepine-induced water intoxication." Br Med J, 2, p. 804
  146. Henry DA, Lawson DH, Reavey P, Renfrew S (1977) "Hyponatraemia during carbamazepine treatment." Br Med J, 1, p. 83-4
  147. Ashton MG, Ball SG, Thomas TH, Lee MR (1977) "Water intoxication associated with carbamazepine tretment." Br Med J, 1, p. 1134-5
  148. Perucca E, Garratt A, Hebdige S, Richens A (1978) "Water intoxication in epileptic patients receiving carbamazepine." J Neural Neurosurg Psychiatry, 41, p. 713-8
  149. Paliwal V, Garg RK, Kar AM, Singh MK (2006) "Oxcarbazepine induced hyponatremic coma." Neurol India, 54, p. 214-5
  150. Belton K, Thomas SH (1999) "Drug-induced syndrome of inappropriate antidiuretic hormone secretion." Postgrad Med J, 75, p. 509-10
  151. Stuart MJ, Cuaso C, Miller M, Oski FA (1975) "Syndrome of recurrent increased secretion of antidiuretic hormone following multiple doses of vincristine." Blood, 45, p. 315-20
  152. Nagappa M, Bhat RR, Sudeep K, Mishra SK, Badhe AS, Hemavathi B (2009) "Vincrisitine-induced acute life-threatening hyponatremia resulting in seizure and coma." Indian J Crit Care Med, 13, p. 167-8
  153. Luzecky MH, Burman KD, Schultz ER (1974) "The syndrome of inappropriate secretion of antidiuretic hormone associated with amitriptyline administration." South Med J, 67, p. 495-7
  154. (1975) "Inappropriate antidiuretic hormone secretion." West J Med, 122, p. 145-9
  155. Cinotti GA, Stirati G, Ruggiero F (1972) "Abnormal water retention and symptomatic hyponatraemia in idiopathic diabetes insipidus during chlorpropamide therapy." Postgrad Med J, 48, p. 107-11
  156. Fonseca VA, Deb M, Gokani SS, Bhandarkar SD (1980) "Chlorpropamide induced syndrome of inappropriate antidiuretic hormone secretion." J Postgrad Med, 26, p. 127-30
  157. Nisbet P (1977) "Chlorpropamide-induced hyponatraemia." Br Med J, 1, p. 904
  158. Kimura T, Shoju M, et al. (1995) "Chlorpropamide-induced ADH release, hyponatremia and central pontine myelinolysis in diabetes mellitus." Tohoku J Exp Med, 177, p. 303-13
  159. Guay DR (2010) Hyponatremia associated with selective serotonin reuptake inhibitors. http://www.ascp.com/publications/tcp/2000/feb/cr_hypo.shtml
  160. Adlakha A, Manocha AP, Bechard DL (1991) "Imipramine-induced syndrome of inappropriate antidiuretic hormone secretion." South Med J, 84, p. 1507-9
  161. Agrawal NK, Rastogi A, Goyal R, Singh SK (2007) "Sertraline-induced hyponatremia in the elderly." CJEM, 9, p. 415
  162. Ritch PS (1988) "Cis-dichlorodiammineplatinum II-induced syndrome of inappropriate secretion of antidiuretic hormone." Cancer, 61, p. 448-50
  163. Levin L, Sealy R, Barron J (1982) "Syndrome of inappropriate antidiuretic hormone secretion following cis-dichlorodiammineplatinum II in a patient with malignant thymoma." Cancer, 50, p. 2279-82
  164. Littlewood TJ, Smith AP (1984) "Syndrome of inappropriate antidiuretic hormone secretion due to treatment of lung cancer with cisplatin." Thorax, 39, p. 636-7
  165. Iyer AV, Krasnow SH, Dufour DR, Arcenas AS (2003) "Sodium-wasting nephropathy caused by cisplatin in a patient with small-cell lung cancer." Clin Lung Cancer, 5, p. 187-9
  166. Okamoto M, Nako Y, Tachibana A, et al. (2002) "Efficacy of phenytoin against hyponatremic seizures due to SIADH after administration of anticancer drugs in a neonate." J Perinatol, 22, p. 247-8
  167. Kagawa K, Fujitaka K, Isobe T, et al. (2001) "Syndrome of inappropriate secretion of ADH (SIADH) following cisplatin administration in a pulmonary adenocarcinoma patient with a malignant pleural effusion." Intern Med, 40, p. 1020-3
  168. Moses AM, Howanitz J, van Gemert M, Miller M (1973) "Clofibrate-induced antidiuresis." J Clin Invest, 52, p. 535-42
  169. O'Regan S, Carson S, Chesney RW, Drummond KN (1977) "Electrolyte and acid-base disturbances in the management of leukemia." Blood, 49, p. 345-53
  170. McCarron M, Wright GD, Roberts SD (1995) "Water intoxication after low dose cyclophosphamide." BMJ, 311, p. 292
  171. Harlow PJ, DeClerck YA, Shore NA, Ortega JA, Carranza A, Heuser E (1979) "A fatal case of inappropriate ADH secretion induced by cyclophosphamide therapy." Cancer, 44, p. 896-8
  172. Kato A, Sugiura T, Yamamoto T, et al. (2008) "Water intoxication induced by low-dose oral cyclophosphamide in a patient with anti-neutrophil cytoplasmic antibody-related glomerulonephritis." NDT Plus, 1, p. 286-8
  173. Jayachandran NV, Chandrasekhara PK, Thomas J, Agrawal S, Narsimulu G (2009) "Cyclophosphamide-associated complications: we need to be aware of SIADH and central pontine myelinolysis." Rheumatology, 48, p. 89-90
  174. Lazarevic V, Hagg E, Wahlin A (2007) "Hiccups and severe hyponatremia associated with high-dose cyclophosphamide in conditioning regimen for allogeneic stem cell transplantation." Am J Hematol, 82, p. 88
  175. DeFronzo RA, Colvin OM, Braine H, Robertson GL, Davis PJ (1974) "Proceedings: cyclophosphamide and the kidney." Cancer, 33, p. 483-91
  176. Munro AH, Crompton GK (1972) "Inappropriate antidiuretic hormone secretion in oat-cell carcinoma of bronchus. Aggravation of hyponatraemia by intravenous cyclophosphamide." Thorax, 27, p. 640-2
  177. Bourgeois JA (2005) "Reversible hyponatremia and venlafaxine." Psychosomatics, 46, p. 495-6
  178. Vanhees SL, Paridaens R, Vansteenkiste JF (2000) "Syndrome of inappropriate antidiuretic hormone associated with chemotherapy-induced tumour lysis in small-cell lung cancer: case report and literature review." Ann Oncol, 11, p. 1061-5
  179. Instituto de Salud Pública de Chile (2013) Sistema de Consulta de Productos Registrados. http://registrosanitario.ispch.gob.cl/
  180. (2017) "Product Information. Vasostrict (vasopressin)." Par Pharmaceutical Inc
  181. (2018) "Product Information. Vasopressin (vasopressin)." APP (Abraxis Pharmaceutical Products)

Drug and food interactions

Moderate

vasopressin food

Applies to: vasopressin

MONITOR: Alcohol may decrease the antidiuretic effect of vasopressin. Clinical studies found that plasma vasopressin levels often decrease during alcohol consumption and increase upon cessation of consumption. In addition, alcoholics were found to have a more pronounced decrease in plasma vasopressin levels when drinking and suppressed vasopressin levels even during alcohol withdrawal as compared to non-alcoholic individuals. The mechanism of this interaction is not fully understood.

MANAGEMENT: Patients should be advised to abstain from alcohol during vasopressin treatment. Hemodynamic monitoring is suggested for patients known to drink alcohol while receiving vasopressin.

References (7)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. Cerner Multum, Inc. "Australian Product Information."
  3. (2017) "Product Information. Vasostrict (vasopressin)." Par Pharmaceutical Inc
  4. Taivainen H, Laitinen K, Tahtela R, Kilanmaa K, Valimaki MJ (1995) "Role of plasma vasopressin in changes of water balance accompanying acute alcohol intoxication." Alcohol Clin Exp Res, 19, p. 759-62
  5. Collins GB, Brosnihan KB, Zuti RA, Messina M, Gupta MK (1992) "Neuroendocrine, fluid balance, and thirst responses to alcohol in alcoholics." Alcohol Clin Exp Res, 16, p. 228-32
  6. Hirschl MM, Derfler K, Bieglmayer C, et al. (1994) "Hormonal derangements in patients with severe alcohol intoxication." Alcohol Clin Exp Res, 18, p. 761-6
  7. Harper KM, Knapp DJ, Criswell HE, Breese GR (2018) "Vasopressin and alcohol: A multifaceted relationship." Psychopharmacology (Berl), 235, p. 3363-79
Moderate

venlafaxine food

Applies to: Effexor XR (venlafaxine)

GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.

MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

References (4)
  1. Warrington SJ, Ankier SI, Turner P (1986) "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology, 15, p. 31-7
  2. Gilman AG, eds., Nies AS, Rall TW, Taylor P (1990) "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc.
  3. (2012) "Product Information. Fycompa (perampanel)." Eisai Inc
  4. (2015) "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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