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Drug Interactions between edaravone and probenecid

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

probenecid edaravone

Applies to: probenecid and edaravone

MONITOR: Coadministration with inhibitors of the uptake transporters organic anion transporter 1 and/or 3 (OAT1, OAT3) may increase the plasma concentration of edaravone sulfate, the active metabolite of edaravone, which is a substrate for these transporters. However, data from in vivo studies are lacking.

MANAGEMENT: Caution is advised if edaravone is used concomitantly with OAT1 and/or OAT3 inhibitors. Dosage adjustments as well as clinical monitoring of edaravone therapy should be considered whenever an OAT1 and/or OAT3 substrate is added to or withdrawn from therapy. Patients should be monitored for the development of adverse effects.

References (1)
  1. (2023) "Product Information. Radicava (edaravone)." Teva Pharma Australia Pty Ltd

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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