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Drug Interactions between Duzallo and osilodrostat

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

lesinurad osilodrostat

Applies to: Duzallo (allopurinol / lesinurad) and osilodrostat

Lesinurad may reduce the blood levels of osilodrostat in some cases, which may make the medication less effective in treating your condition. On the other hand, if you have been receiving both medications, discontinuing lesinurad may increase the blood levels of osilodrostat, which may increase the risk and/or severity of serious and potentially life-threatening side effects such as hypocortisolism (low cortisol levels in the blood), QT prolongation (a heart condition that can lead to irregular heart rhythm), elevated levels of male hormones, high blood pressure, fluid retention, swelling, and hypokalemia (low potassium levels in the blood, which in severe cases can lead to muscle weakness, paralysis, breathing and swallowing difficulties (due to muscle paralysis), and irregular heart rhythm). Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Moderate

allopurinol food

Applies to: Duzallo (allopurinol / lesinurad)

Allopurinol should generally be taken after a meal to reduce side effects. If your daily dose exceeds 300 mg, you may also ask your healthcare provider if it is okay to divide the total daily dose into smaller doses given more frequently instead of once a day, as this may also reduce stomach upset that can happen with allopurinol. It is best to avoid or limit the consumption of alcohol, as it can increase drowsiness or other nervous system side effects of allopurinol. You should also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer