Drug Interactions between Dulcolax Bowel Cleansing and Marblen
This report displays the potential drug interactions for the following 2 drugs:
- Dulcolax Bowel Cleansing (bisacodyl/magnesium citrate)
- Marblen (calcium carbonate/magnesium carbonate)
Interactions between your drugs
calcium carbonate bisacodyl
Applies to: Marblen (calcium carbonate / magnesium carbonate) and Dulcolax Bowel Cleansing (bisacodyl / magnesium citrate)
ADJUST DOSING INTERVAL: By increasing gastric pH, antacids may reduce the resistance of the enteric coating of bisacodyl tablets, resulting in earlier release of bisacodyl and gastric irritation and dyspepsia.
MANAGEMENT: The administration of antacids and bisacodyl should be separated by at least one hour.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
magnesium citrate magnesium carbonate
Applies to: Dulcolax Bowel Cleansing (bisacodyl / magnesium citrate) and Marblen (calcium carbonate / magnesium carbonate)
MONITOR: The concomitant administration of magnesium salts with other magnesium-containing preparations such as antacids or laxatives may increase the risk of magnesium toxicity, particularly in the presence of renal insufficiency. Magnesium toxicity may result in respiratory depression, neuromuscular depression, and heart block.
MANAGEMENT: Clinical and laboratory monitoring for signs of hypermagnesemia and magnesium toxicity is advisable, especially in high-risk patients (e.g., elderly or renally impaired patients).
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
bisacodyl magnesium carbonate
Applies to: Dulcolax Bowel Cleansing (bisacodyl / magnesium citrate) and Marblen (calcium carbonate / magnesium carbonate)
ADJUST DOSING INTERVAL: By increasing gastric pH, antacids may reduce the resistance of the enteric coating of bisacodyl tablets, resulting in earlier release of bisacodyl and gastric irritation and dyspepsia.
MANAGEMENT: The administration of antacids and bisacodyl should be separated by at least one hour.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
Drug and food interactions
calcium carbonate food
Applies to: Marblen (calcium carbonate / magnesium carbonate)
ADJUST DOSING INTERVAL: Administration with food may increase the absorption of calcium. However, foods high in oxalic acid (spinach or rhubarb), or phytic acid (bran and whole grains) may decrease calcium absorption.
MANAGEMENT: Calcium may be administered with food to increase absorption. Consider withholding calcium administration for at least 2 hours before or after consuming foods high in oxalic acid or phytic acid.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
- Cerner Multum, Inc. "Australian Product Information."
- Agencia EspaƱola de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de informaciĆ³n online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
- Mangels AR (2014) "Bone nutrients for vegetarians." Am J Clin Nutr, 100, epub
- Davies NT (1979) "Anti-nutrient factors affecting mineral utilization." Proc Nutr Soc, 38, p. 121-8
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.