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Drug Interactions between drotrecogin alfa and Protexel

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

drotrecogin alfa protein C

Applies to: drotrecogin alfa and Protexel (protein c)

MONITOR: Simultaneous administration of protein C concentrate with tissue plasminogen activators and/or anticoagulants may increase the risk of bleeding. The mechanism of interaction is unknown. Several bleeding episodes have been observed in clinical studies of protein C concentrate for which concurrent anticoagulant medication may have been responsible. However, a contributory effect by protein C cannot be completely ruled out.

MANAGEMENT: Caution is advised if protein C concentrate is used in combination with tissue plasminogen activators and/or anticoagulants. Close clinical and laboratory observation for hematologic complications is recommended. Patients should be advised to promptly report any signs of bleeding to their doctor, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.

References (1)
  1. (2022) "Product Information. Ceprotin (protein C)." Baxter Healthcare Corporation

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Protein c

Therapeutic duplication

The recommended maximum number of medicines in the 'protein C' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'protein C' category:

  • drotrecogin alfa
  • Protexel (protein c)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer