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Drug Interactions between doxorubicin and mitomycin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

DOXOrubicin mitoMYcin

Applies to: doxorubicin and mitomycin

MONITOR: Limited data suggest that mitomycin C and doxorubicin have synergistic cardiotoxicity. In one study of 91 patients who failed doxorubicin therapy and who were then given mitomycin C, 14 (15.3%) developed heart failure, compared with 3 of 89 (3.4%) in a control group of patients who received doxorubicin without mitomycin C.

MANAGEMENT: Until more data are available, careful monitoring of heart function (noninvasive testing with echocardiography and/or multigated blood pool scanning and ECG) is recommended when these drugs are given together or sequentially.

References (1)
  1. Buzdar AU, Legha SS, Tashima CK, et al. (1978) "Adriamycin and mitomycin C: possible synergistic cardiotoxicity." Cancer Treat Rep, 62, p. 1005-8

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Antineoplastic antibiotics

Therapeutic duplication

The recommended maximum number of medicines in the 'antineoplastic antibiotics' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'antineoplastic antibiotics' category:

  • doxorubicin
  • mitomycin

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer