Can you take Doravirine with Focinvez?
1 drug interaction and 4 additional warnings found for the following 2 drugs:
- doravirine
- Focinvez (fosaprepitant)
Drug interactions
Minor drug interactions
Minor:
fosaprepitant doravirine
Applies to: Focinvez (fosaprepitant) and doravirine
Information for this minor interaction is available on the professional version.
Food/lifestyle interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease interactions
4 potential interactions Applies to: 3 conditions, including Liver Disease, Renal Dysfunction, and Peritoneal dialysis.
Liver Disease
Moderate:
doravirine
Doravirine has a moderate potential interaction with Liver Disease.
Doravirine has not been studied in patients with severe liver dysfunction (Child-Pugh C); caution is recommended. No dosage adjustment of doravirine is needed in patients with mild or moderate liver dysfunction (Child-Pugh A or B).
Moderate:
Focinvez
The fosaprepitant in Focinvez has a moderate potential interaction with Liver Disease.
There are no clinical or pharmacokinetic data in patients with severe liver dysfunction (Child-Pugh score greater than 9); therefore, caution and additional monitoring for adverse reactions are recommended when using fosaprepitant in these patients.
Peritoneal dialysis
Moderate:
doravirine
Doravirine has a moderate potential interaction with Peritoneal dialysis.
Doravirine has not been adequately studied in patients with ESRD and has not been studied in patients receiving dialysis; caution is recommended. No dosage adjustment of doravirine is needed in patients with mild, moderate, or severe renal dysfunction.
Renal Dysfunction
Moderate:
doravirine
Doravirine has a moderate potential interaction with Renal Dysfunction.
Doravirine has not been adequately studied in patients with ESRD and has not been studied in patients receiving dialysis; caution is recommended. No dosage adjustment of doravirine is needed in patients with mild, moderate, or severe renal dysfunction.
More resources
doravirine
A total of 207 drugs are known to interact with doravirine.
- Doravirine is in the drug class NNRTIs.
- Doravirine is used to treat HIV-1 Infection.
Focinvez
A total of 471 drugs are known to interact with Focinvez.
- Focinvez is in the drug class NK1 receptor antagonists.
- Focinvez is used to treat Nausea/Vomiting, Chemotherapy Induced.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.