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Drug Interactions between dolasetron and torsemide

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

torsemide dolasetron

Applies to: torsemide and dolasetron

MONITOR CLOSELY: The risk of arrhythmia may be increased in patients taking dolasetron and diuretics. Dolasetron induced ECG changes (PR and QTc prolongation; QRS widening) have been observed in healthy volunteers and in controlled clinical trials. Diuretics may further predispose the patient to arrhythmia by inducing electrolyte abnormalities.

MANAGEMENT: Close clinical and laboratory monitoring for cardiac rhythm and electrolyte disturbances is recommended if this combination is used.

References (1)
  1. (2001) "Product Information. Anzemet (dolasetron)." Hoechst Marion Roussel

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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