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Drug Interactions between dolasetron and rifabutin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

rifabutin dolasetron

Applies to: rifabutin and dolasetron

Blood levels of hydrodolasetron, the major active metabolite of dolasetron, were decreased 28% when dolasetron was given concomitantly for seven days with rifampin. The mechanism is thought to be induction of the metabolism of hydrodolasetron by rifampin via cytochrome P450 enzymes. The clinician may consider monitoring the patient more closely for decreased dolasetron effect if this combination is used. A similar interaction may occur with rifabutin, however, data are lacking.

References (1)
  1. (2001) "Product Information. Anzemet (dolasetron)." Hoechst Marion Roussel

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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