Drug Interactions between dofetilide and Tikosyn
This report displays the potential drug interactions for the following 2 drugs:
- dofetilide
- Tikosyn (dofetilide)
Interactions between your drugs
No interactions were found between dofetilide and Tikosyn. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
dofetilide
A total of 409 drugs are known to interact with dofetilide.
- Dofetilide is in the drug class group III antiarrhythmics.
- Dofetilide is used to treat Arrhythmia.
Tikosyn
A total of 409 drugs are known to interact with Tikosyn.
- Tikosyn is in the drug class group III antiarrhythmics.
- Tikosyn is used to treat Arrhythmia.
Drug and food interactions
dofetilide food
Applies to: dofetilide and Tikosyn (dofetilide)
In vitro data suggest that grapefruit juice may inhibit the CYP450 3A4 first-pass metabolism of dofetilide. Decreased first-pass metabolism may increase dofetilide concentrations and increase the risk of QT interval prolongation and arrhythmias. The clinical significance is unknown, since dofetilide has a high oral bioavailability and a low affinity for CYP450 3A4. The manufacturer recommends caution.
References
- (2001) "Product Information. Tikosyn (dofetilide)." Pfizer U.S. Pharmaceuticals
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Antiarrhythmics
Therapeutic duplication
The recommended maximum number of medicines in the 'antiarrhythmics' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'antiarrhythmics' category:
- dofetilide
- Tikosyn (dofetilide)
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Group iii antiarrhythmics
Therapeutic duplication
The recommended maximum number of medicines in the 'group III antiarrhythmics' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'group III antiarrhythmics' category:
- dofetilide
- Tikosyn (dofetilide)
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.