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Drug Interactions between disulfiram and resmetirom

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

disulfiram resmetirom

Applies to: disulfiram and resmetirom

MONITOR: Coadministration with resmetirom may increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of the CYP450 2C8 isoenzyme. The proposed mechanism, based on in vitro and clinical data, is decreased clearance due to weak inhibition of CYP450 2C8 by resmetirom. In healthy study subjects, when a single dose of the CYP450 2C8 substrate pioglitazone (15 mg) was administered with resmetirom at steady state concentrations (100 mg daily), a 1.5-fold increase in pioglitazone systemic exposure (AUC) was observed. However, the peak plasma concentration (Cmax) of pioglitazone was unchanged.

MANAGEMENT: Caution and clinical monitoring is recommended if resmetirom is coadministered with drugs that are substrates of the CYP450 2C8 isoenzyme. Dosage adjustments as well as closer clinical and laboratory monitoring for the development of adverse effects may be appropriate for some drugs whenever resmetirom is added to or withdrawn from therapy. Individual product labeling should be consulted for further guidance.

References (1)
  1. (2024) "Product Information. Rezdiffra (resmetirom)." Madrigal Pharmaceuticals, Inc.

Drug and food interactions

Major

disulfiram food

Applies to: disulfiram

CONTRAINDICATED: Consumption of ethanol during treatment with disulfiram may cause flushing, nausea, blurred vision, dyspnea, tachypnea, tachycardia, and hypotension. Death has been reported. The mechanism is probably related to inhibition of aldehyde dehydrogenase, the enzyme responsible for the oxidation of acetaldehyde to acetyl CoA. Accumulation of acetaldehyde probably results.

MANAGEMENT: Ethanol should be avoided in patients receiving disulfiram.

References (3)
  1. Jones RO (1949) "Death following the ingestion of alcohol in an antabuse treated patient." Can Med Assoc J, 60, p. 609-12
  2. Stoll D, King LE (1980) "Disulfiram-alcohol skin reaction to beer-containing shampoo." JAMA, 244, p. 2045
  3. van Ieperen L (1984) "Sudden death during disulfiram-ethanol reaction." S Afr Med J, 66, p. 165

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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