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Drug Interactions between disulfiram and Prudoxin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

disulfiram doxepin topical

Applies to: disulfiram and Prudoxin (doxepin topical)

The combination of disulfiram and tricyclic antidepressants may reportedly result in acute organic brain syndrome or dementia. The mechanism is unknown and causality has not been definitely established. Patients should be monitored for symptoms of an interaction. A dosage reduction may be necessary for the tricyclic antidepressant when administered concomitantly with disulfiram.

References (4)
  1. Maany I, Hayashida M, Pfeffer SL, Kron RE (1982) "Possible toxic interaction between disulfiram and amitriptyline." Arch Gen Psychiatry, 39, p. 743-4
  2. MacCallum WA (1969) "Drug interactions in alcoholism treatment." Lancet, 1, p. 313
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  4. Cerner Multum, Inc. "Australian Product Information."

Drug and food interactions

Major

disulfiram food

Applies to: disulfiram

CONTRAINDICATED: Consumption of ethanol during treatment with disulfiram may cause flushing, nausea, blurred vision, dyspnea, tachypnea, tachycardia, and hypotension. Death has been reported. The mechanism is probably related to inhibition of aldehyde dehydrogenase, the enzyme responsible for the oxidation of acetaldehyde to acetyl CoA. Accumulation of acetaldehyde probably results.

MANAGEMENT: Ethanol should be avoided in patients receiving disulfiram.

References (3)
  1. Jones RO (1949) "Death following the ingestion of alcohol in an antabuse treated patient." Can Med Assoc J, 60, p. 609-12
  2. Stoll D, King LE (1980) "Disulfiram-alcohol skin reaction to beer-containing shampoo." JAMA, 244, p. 2045
  3. van Ieperen L (1984) "Sudden death during disulfiram-ethanol reaction." S Afr Med J, 66, p. 165

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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