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Drug Interactions between disulfiram and methylene blue

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

methylene blue disulfiram

Applies to: methylene blue and disulfiram

MONITOR: Delirium has been observed during the coadministration of disulfiram and monoamine oxidase inhibitors (MAOIs). The mechanism of interaction has not been determined. Clinical evidence is limited to one case report in which tranylcypromine was added to a regimen including disulfiram and lithium.

MANAGEMENT: Until further data are available, it may be appropriate to monitor patients for evidence of delirium or other unusual psychiatric reactions when disulfiram is given with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, methylene blue, procarbazine). If symptoms occur, the MAOI should not be discontinued abruptly because of the risk of withdrawal symptoms.

References (1)
  1. Blansjaar BA, Egberts TCG (1995) "Delirium in a patient treated with disulfiram and tranylcypromine." Am J Psychiatry, 152, p. 296

Drug and food interactions

Major

disulfiram food

Applies to: disulfiram

CONTRAINDICATED: Consumption of ethanol during treatment with disulfiram may cause flushing, nausea, blurred vision, dyspnea, tachypnea, tachycardia, and hypotension. Death has been reported. The mechanism is probably related to inhibition of aldehyde dehydrogenase, the enzyme responsible for the oxidation of acetaldehyde to acetyl CoA. Accumulation of acetaldehyde probably results.

MANAGEMENT: Ethanol should be avoided in patients receiving disulfiram.

References (3)
  1. Jones RO (1949) "Death following the ingestion of alcohol in an antabuse treated patient." Can Med Assoc J, 60, p. 609-12
  2. Stoll D, King LE (1980) "Disulfiram-alcohol skin reaction to beer-containing shampoo." JAMA, 244, p. 2045
  3. van Ieperen L (1984) "Sudden death during disulfiram-ethanol reaction." S Afr Med J, 66, p. 165

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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