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Drug Interactions between dirithromycin and guaifenesin / oxtriphylline

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

oxtriphylline dirithromycin

Applies to: guaifenesin / oxtriphylline and dirithromycin

Dirithromycin appears to have little or no effect on theophylline levels. It may rarely increase the plasma clearance of theophylline and plasma theophylline concentrations may be reduced by up to 26%. It is unlikely that the interaction with dirithromycin is clinically significant enough to modify outcome or require treatment adjustments.

References (3)
  1. Upton RA (1991) "Pharmacokinetic interactions between theophylline and other medication (Part I)." Clin Pharmacokinet, 20, p. 66-80
  2. Bachmann K, Nunlee M, Martin M, et al. (1990) "Changes in the steady-state pharmacokinetics of theophylline during treatment with dirithromycin." J Clin Pharmacol, 30, p. 1001-5
  3. Bachmann K, Jauregui L, Sides G, Sullivan TJ (1993) "Steady-state pharmacokinetics of theophylline in COPD patients treated with dirithromycin." J Clin Pharmacol, 33, p. 861-5

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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