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Drug Interactions between diphtheria toxoid / haemophilus b conjugate (prp-omp) vaccine / hepatitis b pediatric vaccine / pertussis, acellular / poliovirus vaccine, inactivated / tetanus toxoid and interferon gamma-1b

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

poliovirus vaccine, inactivated interferon gamma-1b

Applies to: diphtheria toxoid / haemophilus b conjugate (prp-omp) vaccine / hepatitis b pediatric vaccine / pertussis, acellular / poliovirus vaccine, inactivated / tetanus toxoid and interferon gamma-1b

GENERALLY AVOID: The concomitant administration of interferon gamma with vaccines may theoretically increase the risk of an exaggerated immune response. The exact mechanism is unknown, but believed to be related to interferon gamma's immunomodulatory effects.

MANAGEMENT: The manufacturer recommends avoiding concomitant use with vaccines.

References (5)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. Cerner Multum, Inc. "Australian Product Information."
  3. (2021) "Product Information. Imukin (interferon gamma-1b)." Link Medical Products Pty Ltd T/A Link Pharmaceuticals, 4.0
  4. (2021) "Product Information. Actimmune (interferon gamma-1b)." Horizon Therapeutics USA Inc
  5. (2022) "Product Information. Immukin (interferon gamma-1b)." Clinigen Healthcare Ltd
Moderate

tetanus toxoid interferon gamma-1b

Applies to: diphtheria toxoid / haemophilus b conjugate (prp-omp) vaccine / hepatitis b pediatric vaccine / pertussis, acellular / poliovirus vaccine, inactivated / tetanus toxoid and interferon gamma-1b

GENERALLY AVOID: The concomitant administration of interferon gamma with vaccines may theoretically increase the risk of an exaggerated immune response. The exact mechanism is unknown, but believed to be related to interferon gamma's immunomodulatory effects.

MANAGEMENT: The manufacturer recommends avoiding concomitant use with vaccines.

References (5)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. Cerner Multum, Inc. "Australian Product Information."
  3. (2021) "Product Information. Imukin (interferon gamma-1b)." Link Medical Products Pty Ltd T/A Link Pharmaceuticals, 4.0
  4. (2021) "Product Information. Actimmune (interferon gamma-1b)." Horizon Therapeutics USA Inc
  5. (2022) "Product Information. Immukin (interferon gamma-1b)." Clinigen Healthcare Ltd
Moderate

interferon gamma-1b diphtheria toxoid

Applies to: interferon gamma-1b and diphtheria toxoid / haemophilus b conjugate (prp-omp) vaccine / hepatitis b pediatric vaccine / pertussis, acellular / poliovirus vaccine, inactivated / tetanus toxoid

GENERALLY AVOID: The concomitant administration of interferon gamma with vaccines may theoretically increase the risk of an exaggerated immune response. The exact mechanism is unknown, but believed to be related to interferon gamma's immunomodulatory effects.

MANAGEMENT: The manufacturer recommends avoiding concomitant use with vaccines.

References (5)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. Cerner Multum, Inc. "Australian Product Information."
  3. (2021) "Product Information. Imukin (interferon gamma-1b)." Link Medical Products Pty Ltd T/A Link Pharmaceuticals, 4.0
  4. (2021) "Product Information. Actimmune (interferon gamma-1b)." Horizon Therapeutics USA Inc
  5. (2022) "Product Information. Immukin (interferon gamma-1b)." Clinigen Healthcare Ltd
Moderate

interferon gamma-1b pertussis, acellular

Applies to: interferon gamma-1b and diphtheria toxoid / haemophilus b conjugate (prp-omp) vaccine / hepatitis b pediatric vaccine / pertussis, acellular / poliovirus vaccine, inactivated / tetanus toxoid

GENERALLY AVOID: The concomitant administration of interferon gamma with vaccines may theoretically increase the risk of an exaggerated immune response. The exact mechanism is unknown, but believed to be related to interferon gamma's immunomodulatory effects.

MANAGEMENT: The manufacturer recommends avoiding concomitant use with vaccines.

References (5)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. Cerner Multum, Inc. "Australian Product Information."
  3. (2021) "Product Information. Imukin (interferon gamma-1b)." Link Medical Products Pty Ltd T/A Link Pharmaceuticals, 4.0
  4. (2021) "Product Information. Actimmune (interferon gamma-1b)." Horizon Therapeutics USA Inc
  5. (2022) "Product Information. Immukin (interferon gamma-1b)." Clinigen Healthcare Ltd
Moderate

interferon gamma-1b haemophilus b conjugate (PRP-OMP) vaccine

Applies to: interferon gamma-1b and diphtheria toxoid / haemophilus b conjugate (prp-omp) vaccine / hepatitis b pediatric vaccine / pertussis, acellular / poliovirus vaccine, inactivated / tetanus toxoid

GENERALLY AVOID: The concomitant administration of interferon gamma with vaccines may theoretically increase the risk of an exaggerated immune response. The exact mechanism is unknown, but believed to be related to interferon gamma's immunomodulatory effects.

MANAGEMENT: The manufacturer recommends avoiding concomitant use with vaccines.

References (5)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. Cerner Multum, Inc. "Australian Product Information."
  3. (2021) "Product Information. Imukin (interferon gamma-1b)." Link Medical Products Pty Ltd T/A Link Pharmaceuticals, 4.0
  4. (2021) "Product Information. Actimmune (interferon gamma-1b)." Horizon Therapeutics USA Inc
  5. (2022) "Product Information. Immukin (interferon gamma-1b)." Clinigen Healthcare Ltd
Moderate

interferon gamma-1b hepatitis B pediatric vaccine

Applies to: interferon gamma-1b and diphtheria toxoid / haemophilus b conjugate (prp-omp) vaccine / hepatitis b pediatric vaccine / pertussis, acellular / poliovirus vaccine, inactivated / tetanus toxoid

GENERALLY AVOID: The concomitant administration of interferon gamma with vaccines may theoretically increase the risk of an exaggerated immune response. The exact mechanism is unknown, but believed to be related to interferon gamma's immunomodulatory effects.

MANAGEMENT: The manufacturer recommends avoiding concomitant use with vaccines.

References (5)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. Cerner Multum, Inc. "Australian Product Information."
  3. (2021) "Product Information. Imukin (interferon gamma-1b)." Link Medical Products Pty Ltd T/A Link Pharmaceuticals, 4.0
  4. (2021) "Product Information. Actimmune (interferon gamma-1b)." Horizon Therapeutics USA Inc
  5. (2022) "Product Information. Immukin (interferon gamma-1b)." Clinigen Healthcare Ltd

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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