Skip to main content

Can you take Dinoprostone topical with Misoprostol?

1 drug interaction and 7 additional warnings found for the following 2 drugs:

Add/remove drugs

Drug interactions

Major drug interactions

Major:

miSOPROStol dinoprostone topical

Applies to: misoprostol and dinoprostone topical

Using dinoprostone topical together with miSOPROStol is generally not recommended.

Combining these medications may overstimulate the uterus and potentially cause tear or rupture, particularly if the cervix is not adequately dilated.

Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact.

It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition.

It can be intentional, when combining drugs with similar actions adds demonstrated therapeutic benefit — or unintentional, such as when a patient sees multiple prescribers or fills prescriptions at more than one pharmacy, which can lead to adverse effects.

Duplication:

Prostaglandin abortifacients

The recommended maximum number of medicines in the 'prostaglandin abortifacients' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'prostaglandin abortifacients' category:

  • dinoprostone topical
  • misoprostol

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

Food/lifestyle interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease interactions

6 potential interactions Applies to: 6 conditions, including Asthma, Hypotension, Inflammatory Bowel Disease, Dehydration, and Cardiovascular Conditions and Disorders.

Asthma

Moderate:

dinoprostone topical

Dinoprostone topical has a moderate potential interaction with Asthma.

The use of dinoprostone may be associated with bronchospasm, decreased pulmonary blood flow, and/or increased pulmonary arterial pressure. Dinoprostone induces contraction of smooth muscle, including smooth muscle of the respiratory tract. Therapy with dinoprostone should be administered cautiously in patients with asthma, or history of childhood asthma, even in the absence of asthma attacks in adulthood.

Cardiovascular Conditions and Disorders

Moderate:

misoprostol

miSOPROStol has a moderate potential interaction with Cardiovascular Conditions and Disorders.

Caution should be employed when administering misoprostol to patients with preexisting cardiovascular disease.

Dehydration

Moderate:

misoprostol

miSOPROStol has a moderate potential interaction with Dehydration.

Diarrhea may occur in up to 40% of patients receiving misoprostol. Misoprostol should be administered cautiously in patients with underlying conditions such as inflammatory bowel disease and dehydration. Careful monitoring during therapy is recommended.

Glaucoma/Intraocular Hypertension

Moderate:

dinoprostone topical

Dinoprostone topical has a moderate potential interaction with Glaucoma/Intraocular Hypertension.

Caution should be exercised when administering dinoprostone topical in patients with a history of glaucoma.

Hypotension

Moderate:

dinoprostone topical

Dinoprostone topical has a moderate potential interaction with Hypotension.

Therapy with dinoprostone should be administered cautiously in patients with a history of hypotension.

Inflammatory Bowel Disease

Moderate:

misoprostol

miSOPROStol has a moderate potential interaction with Inflammatory Bowel Disease.

Diarrhea may occur in up to 40% of patients receiving misoprostol. Misoprostol should be administered cautiously in patients with underlying conditions such as inflammatory bowel disease and dehydration. Careful monitoring during therapy is recommended.

Report options

Loading...
QR code containing a link to this page

More resources

dinoprostone topical

A total of 6 drugs are known to interact with dinoprostone topical.

misoprostol

A total of 15 drugs are known to interact with misoprostol.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer