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Drug Interactions between Dilex-G and Primaxin IM

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

dyphylline imipenem

Applies to: Dilex-G (dyphylline / guaifenesin) and Primaxin IM (cilastatin / imipenem)

MONITOR: Some case reports suggest an increased risk of seizures when theophylline and imipenem are coadministered. The mechanism is unknown. Patients receiving large doses of either drug and/or with renal dysfunction may be at a higher risk.

MANAGEMENT: Dosing should be individualized and patients should be closely monitored for signs of neurotoxicity (e.g., confusion, seizures, myoclonic activity).

References

  1. Semel JD, Allen N (1991) "Seizures in patients simultaneously receiving theophylline and imipenem or ciprofloxacin or metronidazole." South Med J, 84, p. 465-8

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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