Skip to Content

Drug interactions between digoxin and Vitamin D3

Results for the following 2 drugs:
digoxin
Vitamin D3 (cholecalciferol)

Interactions between your drugs

Moderate

digoxin ↔ cholecalciferol

Applies to:digoxin and Vitamin D3 (cholecalciferol)

Cholecalciferol can increase the levels of calcium in your body. Since calcium can enhance the effects of digoxin on the heart, using too much cholecalciferol can cause digoxin toxicity and irregular heart rhythm. If your doctor prescribes these medications together, you may need a dose adjustment or more frequent blood tests to monitor calcium and digoxin levels. You should use cholecalciferol exactly as directed and avoid large increases in your daily dietary calcium intake while using cholecalciferol. Contact your doctor if you experience symptoms that could indicate high blood calcium, such as weakness, fatigue, headache, drowsiness, dizziness, ringing in the ears, loss of appetite, nausea, vomiting, constipation, dry mouth, a metallic taste in the mouth, bone or muscle pain, incoordination, frequent urination, and weight loss. You should also seek medical attention if you experience symptoms of digoxin toxicity such as nausea, vomiting, blurred vision, slow pulse, or irregular heartbeats. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2017 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Hide