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Drug Interactions between digoxin and Vitamin D3

This report displays the potential drug interactions for the following 2 drugs:

  • digoxin
  • Vitamin D3 (cholecalciferol)

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Interactions between your drugs


digoxin cholecalciferol

Applies to: digoxin and Vitamin D3 (cholecalciferol)

Cholecalciferol can increase the levels of calcium in your body. Since calcium can enhance the effects of digoxin on the heart, using too much cholecalciferol can cause digoxin toxicity and irregular heart rhythm. If your doctor prescribes these medications together, you may need a dose adjustment or more frequent blood tests to monitor calcium and digoxin levels. You should use cholecalciferol exactly as directed and avoid large increases in your daily dietary calcium intake while using cholecalciferol. Contact your doctor if you experience symptoms that could indicate high blood calcium, such as weakness, fatigue, headache, drowsiness, dizziness, ringing in the ears, loss of appetite, nausea, vomiting, constipation, dry mouth, a metallic taste in the mouth, bone or muscle pain, incoordination, frequent urination, and weight loss. You should also seek medical attention if you experience symptoms of digoxin toxicity such as nausea, vomiting, blurred vision, slow pulse, or irregular heartbeats. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions


digoxin food

Applies to: digoxin

Information for this minor interaction is only available at a professional reading level.

For clinical details see professional interaction data.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.