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Drug Interactions between digitoxin and Mycobutin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

digitoxin rifabutin

Applies to: digitoxin and Mycobutin (rifabutin)

MONITOR: Rifampin may decrease the plasma concentrations of digitoxin by inducing its CYP450 hepatic metabolism.

MANAGEMENT: While receiving rifampin, the patient should be monitored for inadequate response to digitoxin. Dosage should be increased as necessary. The clinician should consider monitoring the patient for arrhythmia control, signs and symptoms of heart failure, and serum digitoxin concentrations.

References (8)
  1. Venkatesan K (1992) "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet, 22, p. 47-65
  2. Borcherding SM, Baciewicz AM, Self TH (1992) "Update on rifampin drug interactions." Arch Intern Med, 152, p. 711-6
  3. Bussey HI, Merritt GJ, Hill EG (1984) "The influence of rifampin on quinidine and digoxin." Arch Intern Med, 144, p. 1021-3
  4. Poor DM, Self TH, Davis HL (1983) "Interaction of rifampin and digitoxin." Arch Intern Med, 143, p. 599
  5. (2001) "Product Information. Rifadin (rifampin)." Hoechst Marion Roussel
  6. Boman G, Eliasson K, Odar-Cederlof I (1980) "Acute cardiac failure during treatment with digoxin--an interaction with rifampicin." Br J Clin Pharmacol, 10, p. 89-90
  7. Novi C, Bissoli F, Simonati V, Volpini T, Baroli A, Vignati G (1980) "Rifampin and digoxin: possible drug interaction in a dialysis patient." JAMA, 244, p. 2521-2
  8. Strayhorn VA, Baciewicz AM, Self TH (1997) "Update on rifampin drug interactions, III." Arch Intern Med, 157, p. 2453-8

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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