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Drug Interactions between digitoxin and midodrine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

digitoxin midodrine

Applies to: digitoxin and midodrine

MONITOR: Midodrine when administered with any agent that may slow the heart rate (i.e., cardiac glycosides, beta blockers, tricyclic antidepressants) may enhance or precipitate bradycardia, AV block or arrhythmia. The mechanism may be related to vagal reflexive slowing of the heart after midodrine administration.

MANAGEMENT: If midodrine and cardiac glycosides are administered concomitantly, patients should be monitored for cardiac abnormalities. Patients should be advised to promptly notify their physician if they experience a slow pulse, dizziness, syncope, or cardiac awareness.

References (1)
  1. (2001) "Product Information. ProAmatine (midodrine)." Roberts Pharmaceutical Corporation

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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