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Drug Interactions between digitoxin and epoprostenol

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

digitoxin epoprostenol

Applies to: digitoxin and epoprostenol

Epoprostenol may decrease clearance of oral digoxin. The mechanism has not been determined. Theoretically, this interaction could lead to higher digoxin plasma concentrations and could potentiate toxicity. One pilot study noted a 15% decrease in clearance (which was statistically significant) on day 3 of administration. However, this change was not apparent by day 87. The change in digoxin clearance would not be expected to be clinically significant, except possibly in patients with higher baseline digoxin levels. Epoprostenol and digoxin have been used safely together during epoprostenol clinical trials.

References (1)
  1. Carlton LD, Patterson JH, Mattson CN, Schmith VD (1996) "The effects of epoprostenol on drug disposition. 1: a pilot study of the pharmacokinetics of digoxin with and without epoprostenol in patients with congestive heart failure." J Clin Pharmacol, 36, p. 247-56

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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