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Drug interactions between Diflucan and Macrobid

Results for the following 2 drugs:
Diflucan (fluconazole)
Macrobid (nitrofurantoin)

Interactions between your drugs

Moderate

fluconazole nitrofurantoin

Applies to: Diflucan (fluconazole) and Macrobid (nitrofurantoin)

Using fluconazole together with nitrofurantoin may increase the risk of liver and lung toxicity. This may be more likely to occur in older adults or those with a debilitating condition. Talk with your doctor before using these medications together. Call the doctor if you have side effects such as cough, shortness of breath, fatigue, or pain. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Drug and food interactions

No results found in our database - however, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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