Can you take Difelikefalin with Iophen DM NR?
1 drug interaction and 3 additional warnings found for the following 2 drugs:
- difelikefalin
- Iophen DM NR (dextromethorphan/guaifenesin)
Drug interactions
Moderate drug interactions
Moderate:
dextromethorphan difelikefalin
Applies to: Iophen DM NR (dextromethorphan / guaifenesin) and difelikefalin
Using dextromethorphan together with difelikefalin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
dextromethorphan Food/Lifestyle
Applies to: Iophen DM NR (dextromethorphan / guaifenesin)
Alcohol can increase the nervous system side effects of dextromethorphan such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with dextromethorphan. Do not use more than the recommended dose of dextromethorphan, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Moderate:
difelikefalin Food/Lifestyle
Applies to: difelikefalin
Alcohol can increase the nervous system side effects of difelikefalin such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with difelikefalin. Do not use more than the recommended dose of difelikefalin, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Disease interactions
1 potential interaction Applies to: 1 condition, including Liver Disease.
Liver Disease
Moderate:
difelikefalin
Difelikefalin has a moderate potential interaction with Liver Disease.
The use of difelikefalin in patients with severe hepatic impairment has not been evaluated and is not recommended. A population pharmacokinetic analysis has shown that dosage adjustments are not needed in patients with mild to moderate hepatic impairment. The metabolism of this drug is unknown.
More resources
difelikefalin
A total of 257 drugs are known to interact with difelikefalin.
- Difelikefalin is in the drug class peripheral opioid receptor agonists.
- Difelikefalin is used to treat Chronic Kidney Disease-Associated Pruritus.
Iophen DM NR
A total of 375 drugs are known to interact with Iophen DM NR.
- Iophen dm nr is in the drug class upper respiratory combinations.
- Iophen dm nr is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.