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Drug Interactions between Diarrest and Dolobid

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

diflunisal attapulgite

Applies to: Dolobid (diflunisal) and Diarrest (attapulgite)

Concomitant administration of diflunisal and aluminum-containing products reduces the oral bioavailability of diflunisal by up to 40%. Doses of diflunisal and aluminum-containing products should be separated by at least 2 hours to ensure adequate absorption of diflunisal. Patients should be monitored for altered clinical effects of diflunisal.

References

  1. D'Arcy PF, McElnay JC "Drug-antacid interactions: assessment of clinical importance." Drug Intell Clin Pharm 21 (1987): 607-17
  2. Verbeeck R, Tjandramaga TB, Mullie A, Verbesselt R, de Schepper PJ "Effect of aluminum hydroxide on diflunisal absorption." Br J Clin Pharmacol 7 (1979): 519-22
  3. "Product Information. Dolobid (diflunisal)." Merck & Co., Inc PROD (2001):

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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