Skip to Content

Drug interactions between Di-Phen and Gamulin Rh

Results for the following 2 drugs:
Di-Phen (phenytoin)
Gamulin Rh (rho (d) immune globulin)

Interactions between your drugs


phenytoin RHo (D) immune globulin

Applies to: Di-Phen (phenytoin) and Gamulin Rh (rho (d) immune globulin)

The use of phenytoin and other similar anticonvulsants has been associated with an allergic reaction that causes inflammation of the heart, liver, or other organs. There is limited evidence to suggest that immune globulins may increase the risk of developing the reaction, although it has not been proven. Before receiving treatment with RHo (D) immune globulin, let your doctor know if you are using phenytoin. Contact your doctor immediately if you develop a rash, skin redness, itching, fever, joint pain or swelling, unusual bleeding or bruising, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, light-colored stools, yellowing of the skin or eyes, difficulty breathing, chest tightness, or chest pain during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Drug and food interactions


phenytoin food

Applies to: Di-Phen (phenytoin)

Phenytoin levels may decrease when the suspension is given with enteral feedings. This could lead to a loss of seizure control. You could interrupt the feeding for 2 hours before and after the phenytoin dose. Alternatively, you may give the phenytoin suspension diluted in water and flush the tube with water after administration. These would make it easier for your body to absorb the medication. However, this still may not entirely avoid the interaction and may not always be feasible. You should have your phenytoin levels checked upon starting and stopping of enteral feedings. In addition, using phenytoin together with food may alter the effects of phenytoin. Contact your doctor if you experience worsening of seizure control or symptoms of toxicity, including twitching eye movements, slurred speech, loss of balance, tremor, muscle stiffness or weakness, nausea, vomiting, feeling light-headed, fainting, and slow or shallow breathing. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Ask your doctor before making any changes to your therapy.

Switch to professional interaction data

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.