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Drug Interactions between DHEA and tranexamic acid

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

tranexamic acid dehydroepiandrosterone (prasterone)

Applies to: tranexamic acid and DHEA (dehydroepiandrosterone)

MONITOR CLOSELY: There are no clinical data on the use of tranexamic acid in combination with estrogens or selective estrogen receptor modulators. Because tranexamic acid is an antifibrinolytic agent, concomitant use may further exacerbate the risk of thrombotic events, including venous thromboembolism as well as arterial thromboses such as stroke and myocardial infarction, associated with estrogenic therapy. During postmarketing use of tranexamic acid for the treatment of cyclic heavy menstrual bleeding, there have been reports of venous and arterial thrombotic events in women who used tranexamic acid during treatment with combination hormonal contraceptives.

MANAGEMENT: Caution and close monitoring for thromboembolic adverse effects are recommended if tranexamic acid is prescribed with estrogens or selective estrogen receptor modulators. Patients should be advised to seek medical attention immediately if they experience potential signs and symptoms of blood clots such as chest pain, shortness of breath, hemoptysis, hematuria, sudden loss of vision, and pain, redness or swelling in an extremity.

References (6)
  1. (2001) "Product Information. Cyklokapron (tranexamic acid)." Pharmacia and Upjohn
  2. van Hylckama Vlieg A, Helmerhorst FM, Vandenbroucke JP, Doggen CJ, Rosendaal FR (2009) "The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study." BMJ, 339, b2921
  3. Lidegaard O, Lokkegaard E, Svendsen AL, Agger C (2009) "Hormonal contraception and risk of venous thromboembolism: national follow-up study." BMJ, 339, b2890
  4. (2022) "Product Information. Lysteda (tranexamic acid)." Xanodyne Pharmaceuticals Inc
  5. Rosendaal FR, Van Hylckama Vlieg A, Tanis BC, Helmerhorst FM (2003) "Estrogens, progestogens and thrombosis." J Thromb Haemost, 1, p. 1371-80
  6. Gomes MP, Deitcher SR (2004) "Risk of venous thromboembolic disease associated with hormonal contraceptives and hormone replacement therapy: a clinical review." Arch Intern Med, 164, p. 1965-76

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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